Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia

BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and suppresses transformation of immature T-cells in mice. However, the contribution of Fanconi-BRCA pathway deficiency to human T-cell acute lymphoblastic leukemia (T-ALL) remains undefined. We identified point mutations in 9 (...

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Detalles Bibliográficos
Autores principales: Pouliot, Gayle P., Degar, James, Hinze, Laura, Kochupurakkal, Bose, Vo, Chau D., Burns, Melissa A., Moreau, Lisa, Ganesa, Chirag, Roderick, Justine, Peirs, Sofie, Menten, Bjorn, Loh, Mignon L., Hunger, Stephen P., Silverman, Lewis B., Harris, Marian H., Stevenson, Kristen E., Weinstock, David M., Weng, Andrew P., Van Vlierberghe, Pieter, D’Andrea, Alan D., Gutierrez, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853288/
https://www.ncbi.nlm.nih.gov/pubmed/31721781
http://dx.doi.org/10.1371/journal.pone.0221288

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