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Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging

RNA molecules generated by ribonuclease cleavage sometimes harbor a 2′,3′-cyclic phosphate (cP) at their 3′-ends. Those cP-containing RNAs (cP-RNAs) form a hidden layer of transcriptome because standard RNA-seq cannot capture them as a result of cP’s prevention of an adapter ligation reaction. Here...

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Detalles Bibliográficos
Autores principales:	Shigematsu, Megumi, Morichika, Keisuke, Kawamura, Takuya, Honda, Shozo, Kirino, Yohei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853296/ https://www.ncbi.nlm.nih.gov/pubmed/31721758 http://dx.doi.org/10.1371/journal.pgen.1008469

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