The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the microprocessor complex required for miRNA synthesis. Comp...

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Detalles Bibliográficos
Autores principales: Loo, Tsui Han, Ye, Xiaoqian, Chai, Ruth Jinfen, Ito, Mitsuteru, Bonne, Gisèle, Ferguson-Smith, Anne C, Stewart, Colin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853637/
https://www.ncbi.nlm.nih.gov/pubmed/31686651
http://dx.doi.org/10.7554/eLife.49485

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