Genome-wide Association Study Identifies Genetic Variants Associated With Early and Sustained Response to (Pegylated) Interferon in Chronic Hepatitis B Patients: The GIANT-B Study

BACKGROUND: (Pegylated) Interferon ([Peg]IFN) therapy leads to response in a minority of chronic hepatitis B (CHB) patients. Host genetic determinants of response are therefore in demand. METHODS: In this genome-wide association study (GWAS), CHB patients, treated with (Peg)IFN for at least 12 weeks...

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Autores principales: Brouwer, Willem P, Chan, Henry L Y, Lampertico, Pietro, Hou, Jinlin, Tangkijvanich, Pisit, Reesink, Hendrik W, Zhang, Wenhong, Mangia, Alessandra, Tanwandee, Tawesak, Montalto, Giuseppe, Simon, Kris, Ormeci, Necati, Chen, Liang, Tabak, Fehmi, Gunsar, Fulya, Flisiak, Robert, Ferenci, Peter, Akdogan, Meral, Akyuz, Filiz, Hirankarn, Nattiya, Jansen, Louis, Wong, Vincent Wai-Sun, Soffredini, Roberta, Liang, Xieer, Chen, Shalom, Groothuismink, Zwier M A, Santoro, Rosanna, Jaroszewicz, Jerzy, Ozaras, Resat, Kozbial, Karin, Brahmania, Mayur, Xie, Qing, Chotiyaputta, Watcharasak, Xun, Qi, Pazgan-Simon, Monika, Oztas, Erkin, Verhey, Elke, Montanari, Noé R, Sun, Jian, Hansen, Bettina E, Boonstra, Andre, Janssen, Harry L A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853659/
https://www.ncbi.nlm.nih.gov/pubmed/30715261
http://dx.doi.org/10.1093/cid/ciz084

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