Discovering novel mutation signatures by latent Dirichlet allocation with variational Bayes inference

MOTIVATION: A cancer genome includes many mutations derived from various mutagens and mutational processes, leading to specific mutation patterns. It is known that each mutational process leads to characteristic mutations, and when a mutational process has preferences for mutations, this situation i...

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Detalles Bibliográficos
Autores principales: Matsutani, Taro, Ueno, Yuki, Fukunaga, Tsukasa, Hamada, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853711/
https://www.ncbi.nlm.nih.gov/pubmed/30993319
http://dx.doi.org/10.1093/bioinformatics/btz266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853711/
https://www.ncbi.nlm.nih.gov/pubmed/30993319
http://dx.doi.org/10.1093/bioinformatics/btz266

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