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Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis fr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853824/ https://www.ncbi.nlm.nih.gov/pubmed/31568647 http://dx.doi.org/10.1002/cam4.2195 |
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author | Ronchi, Andrea Cozzolino, Immacolata Montella, Marco Panarese, Iacopo Zito Marino, Federica Rossetti, Sabrina Chieffi, Paolo Accardo, Marina Facchini, Gaetano Franco, Renato |
author_facet | Ronchi, Andrea Cozzolino, Immacolata Montella, Marco Panarese, Iacopo Zito Marino, Federica Rossetti, Sabrina Chieffi, Paolo Accardo, Marina Facchini, Gaetano Franco, Renato |
author_sort | Ronchi, Andrea |
collection | PubMed |
description | Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis. |
format | Online Article Text |
id | pubmed-6853824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68538242019-12-16 Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features Ronchi, Andrea Cozzolino, Immacolata Montella, Marco Panarese, Iacopo Zito Marino, Federica Rossetti, Sabrina Chieffi, Paolo Accardo, Marina Facchini, Gaetano Franco, Renato Cancer Med Clinical Cancer Research Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis. John Wiley and Sons Inc. 2019-09-30 /pmc/articles/PMC6853824/ /pubmed/31568647 http://dx.doi.org/10.1002/cam4.2195 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Ronchi, Andrea Cozzolino, Immacolata Montella, Marco Panarese, Iacopo Zito Marino, Federica Rossetti, Sabrina Chieffi, Paolo Accardo, Marina Facchini, Gaetano Franco, Renato Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features |
title | Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features |
title_full | Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features |
title_fullStr | Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features |
title_full_unstemmed | Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features |
title_short | Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features |
title_sort | extragonadal germ cell tumors: not just a matter of location. a review about clinical, molecular and pathological features |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853824/ https://www.ncbi.nlm.nih.gov/pubmed/31568647 http://dx.doi.org/10.1002/cam4.2195 |
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