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Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation

B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and tra...

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Autores principales: Yang, Haopeng, Green, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853842/
https://www.ncbi.nlm.nih.gov/pubmed/31788471
http://dx.doi.org/10.3389/fcell.2019.00272
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author Yang, Haopeng
Green, Michael R.
author_facet Yang, Haopeng
Green, Michael R.
author_sort Yang, Haopeng
collection PubMed
description B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context.
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spelling pubmed-68538422019-11-29 Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation Yang, Haopeng Green, Michael R. Front Cell Dev Biol Cell and Developmental Biology B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context. Frontiers Media S.A. 2019-11-07 /pmc/articles/PMC6853842/ /pubmed/31788471 http://dx.doi.org/10.3389/fcell.2019.00272 Text en Copyright © 2019 Yang and Green. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yang, Haopeng
Green, Michael R.
Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
title Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
title_full Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
title_fullStr Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
title_full_unstemmed Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
title_short Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
title_sort epigenetic programing of b-cell lymphoma by bcl6 and its genetic deregulation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853842/
https://www.ncbi.nlm.nih.gov/pubmed/31788471
http://dx.doi.org/10.3389/fcell.2019.00272
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