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Serotonin 5-HT(2C) Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro

A non-synonymous single nucleotide polymorphism of the human serotonin 5-HT(2C) receptor (5-HT(2C)R) gene that converts a cysteine to a serine at amino acid codon 23 (Cys23Ser) appears to impact 5-HT(2C)R pharmacology at a cellular and systems level. We hypothesized that the Cys23Ser alters 5-HT(2C)...

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Detalles Bibliográficos
Autores principales:	Land, Michelle A., Chapman, Holly L., Davis-Reyes, Brionna D., Felsing, Daniel E., Allen, John A., Moeller, F. Gerard, Elferink, Lisa A., Cunningham, Kathryn A., Anastasio, Noelle C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853916/ https://www.ncbi.nlm.nih.gov/pubmed/31723224 http://dx.doi.org/10.1038/s41598-019-53124-2

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