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Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration
Bioactive coatings have the potential to improve the bony integration of mechanically loaded orthopedic ceramic implants. Using the concept of mimicking the natural bone surface, four different coatings of varying thickness on a zirconia toughened alumina (ZTA) ceramic implant were investigated rega...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853946/ https://www.ncbi.nlm.nih.gov/pubmed/31723174 http://dx.doi.org/10.1038/s41598-019-53094-5 |
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author | Pobloth, Anne-Marie Mersiowsky, Max J. Kliemt, Luisa Schell, Hanna Dienelt, Anke Pfitzner, Berit M. Burgkart, Rainer Detsch, Rainer Wulsten, Dag Boccaccini, Aldo R. Duda, Georg N. |
author_facet | Pobloth, Anne-Marie Mersiowsky, Max J. Kliemt, Luisa Schell, Hanna Dienelt, Anke Pfitzner, Berit M. Burgkart, Rainer Detsch, Rainer Wulsten, Dag Boccaccini, Aldo R. Duda, Georg N. |
author_sort | Pobloth, Anne-Marie |
collection | PubMed |
description | Bioactive coatings have the potential to improve the bony integration of mechanically loaded orthopedic ceramic implants. Using the concept of mimicking the natural bone surface, four different coatings of varying thickness on a zirconia toughened alumina (ZTA) ceramic implant were investigated regarding their osseointegration in a drill-hole model in sheep. The hypothesis that a bioactive coating of ZTA ceramics would facilitate cancellous bone integration was investigated. The bioactive coatings consisted of either a layer of covalently bound multi phosphonate molecules (chemical modification = CM), a nano hydoxyapatite coating (HA), or two different bioactive glass (BG) coatings in micrometer thickness, forming a hydroxyl-carbonate apatite layer on the implant surface in vivo (dip-coated 45S5 = DipBG; sol-gel 70S30C = SGBG). Coated surfaces were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. After 12 weeks, osseointegration was evaluated via mechanical push-out testing and histology. HA enhanced the maximum push-out force (HA: mean 3573.85 ± 1119.91 N; SGBG: mean 1691.57 ± 986.76 N; p = 0.046), adhesive shear strength (HA: mean 9.82 ± 2.89 MPA; SGBG: mean 4.57 ± 2.65 MPA; p = 0.025), and energy release rate (HA: mean 3821.95 ± 1474.13 J/mm(2); SGBG: mean 1558.47 ± 923.47 J/mm(2); p = 0.032) compared to SGBG. The implant-bone interfacial stiffness increased by CM compared to SGBG coating (CM: mean 6258.06 ± 603.80 N/mm; SGBG: mean 3565.57 ± 1705.31 n/mm; p = 0.038). Reduced mechanical osseointegration of SGBG coated implants could be explained histologically by a foreign body reaction surrounding the implants. |
format | Online Article Text |
id | pubmed-6853946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68539462019-11-19 Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration Pobloth, Anne-Marie Mersiowsky, Max J. Kliemt, Luisa Schell, Hanna Dienelt, Anke Pfitzner, Berit M. Burgkart, Rainer Detsch, Rainer Wulsten, Dag Boccaccini, Aldo R. Duda, Georg N. Sci Rep Article Bioactive coatings have the potential to improve the bony integration of mechanically loaded orthopedic ceramic implants. Using the concept of mimicking the natural bone surface, four different coatings of varying thickness on a zirconia toughened alumina (ZTA) ceramic implant were investigated regarding their osseointegration in a drill-hole model in sheep. The hypothesis that a bioactive coating of ZTA ceramics would facilitate cancellous bone integration was investigated. The bioactive coatings consisted of either a layer of covalently bound multi phosphonate molecules (chemical modification = CM), a nano hydoxyapatite coating (HA), or two different bioactive glass (BG) coatings in micrometer thickness, forming a hydroxyl-carbonate apatite layer on the implant surface in vivo (dip-coated 45S5 = DipBG; sol-gel 70S30C = SGBG). Coated surfaces were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. After 12 weeks, osseointegration was evaluated via mechanical push-out testing and histology. HA enhanced the maximum push-out force (HA: mean 3573.85 ± 1119.91 N; SGBG: mean 1691.57 ± 986.76 N; p = 0.046), adhesive shear strength (HA: mean 9.82 ± 2.89 MPA; SGBG: mean 4.57 ± 2.65 MPA; p = 0.025), and energy release rate (HA: mean 3821.95 ± 1474.13 J/mm(2); SGBG: mean 1558.47 ± 923.47 J/mm(2); p = 0.032) compared to SGBG. The implant-bone interfacial stiffness increased by CM compared to SGBG coating (CM: mean 6258.06 ± 603.80 N/mm; SGBG: mean 3565.57 ± 1705.31 n/mm; p = 0.038). Reduced mechanical osseointegration of SGBG coated implants could be explained histologically by a foreign body reaction surrounding the implants. Nature Publishing Group UK 2019-11-13 /pmc/articles/PMC6853946/ /pubmed/31723174 http://dx.doi.org/10.1038/s41598-019-53094-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pobloth, Anne-Marie Mersiowsky, Max J. Kliemt, Luisa Schell, Hanna Dienelt, Anke Pfitzner, Berit M. Burgkart, Rainer Detsch, Rainer Wulsten, Dag Boccaccini, Aldo R. Duda, Georg N. Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
title | Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
title_full | Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
title_fullStr | Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
title_full_unstemmed | Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
title_short | Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
title_sort | bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853946/ https://www.ncbi.nlm.nih.gov/pubmed/31723174 http://dx.doi.org/10.1038/s41598-019-53094-5 |
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