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Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease

About a quarter of children with new onset of Kawasaki disease (KD) encounter coronary arterial involvement. While KD is known to cause vasculitis of medium-sized vessels, few studies have been done to study the involvement of the microcirculation. We aimed to investigate the association between cor...

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Autores principales: Lim, Edward Jianyang, Aris, Izzuddin M., Choo, Jonathan, Wong, Tien Yin, Li, Ling-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853953/
https://www.ncbi.nlm.nih.gov/pubmed/31723195
http://dx.doi.org/10.1038/s41598-019-53220-3
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author Lim, Edward Jianyang
Aris, Izzuddin M.
Choo, Jonathan
Wong, Tien Yin
Li, Ling-Jun
author_facet Lim, Edward Jianyang
Aris, Izzuddin M.
Choo, Jonathan
Wong, Tien Yin
Li, Ling-Jun
author_sort Lim, Edward Jianyang
collection PubMed
description About a quarter of children with new onset of Kawasaki disease (KD) encounter coronary arterial involvement. While KD is known to cause vasculitis of medium-sized vessels, few studies have been done to study the involvement of the microcirculation. We aimed to investigate the association between coronary arterial dilatation and retinal microvasculature in a pilot setting, in order to further study the pathophysiological mechanism of KD from the perspective of small vessels changes. We performed a cross-sectional, observational, hospital-based study on 11 children aged 2 years and above with new-onset KD. Cardiac imaging technicians performed the echocardiographic examinations and recorded right coronary artery (RCA), left coronary artery (LCA) and left anterior descending artery (LAD). Qualified retinal graders reviewed and graded standardised retinal photographs to assess retinal microvascular parameters. Among 11 participants, there were 7 boys and 4 girls. Median and interquartile range of participants’ age were 5.92 (3.08) years. After adjusting for age and sex, each unit increase in LAD (mm) was significantly associated with increment of retinal arteriolar tortuosity (4.25 × 10(−5) units, 95% Confidence Interval: 1.19, 7.32). Retinal arteriolar geometric changes were associated with LAD dilatation in 11 children with new onset of KD. Our pilot provided proof-of-concept that retinal imaging might be useful for detecting coronary arterial involvement in young children with KD and it needs further investigation.
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spelling pubmed-68539532019-11-19 Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease Lim, Edward Jianyang Aris, Izzuddin M. Choo, Jonathan Wong, Tien Yin Li, Ling-Jun Sci Rep Article About a quarter of children with new onset of Kawasaki disease (KD) encounter coronary arterial involvement. While KD is known to cause vasculitis of medium-sized vessels, few studies have been done to study the involvement of the microcirculation. We aimed to investigate the association between coronary arterial dilatation and retinal microvasculature in a pilot setting, in order to further study the pathophysiological mechanism of KD from the perspective of small vessels changes. We performed a cross-sectional, observational, hospital-based study on 11 children aged 2 years and above with new-onset KD. Cardiac imaging technicians performed the echocardiographic examinations and recorded right coronary artery (RCA), left coronary artery (LCA) and left anterior descending artery (LAD). Qualified retinal graders reviewed and graded standardised retinal photographs to assess retinal microvascular parameters. Among 11 participants, there were 7 boys and 4 girls. Median and interquartile range of participants’ age were 5.92 (3.08) years. After adjusting for age and sex, each unit increase in LAD (mm) was significantly associated with increment of retinal arteriolar tortuosity (4.25 × 10(−5) units, 95% Confidence Interval: 1.19, 7.32). Retinal arteriolar geometric changes were associated with LAD dilatation in 11 children with new onset of KD. Our pilot provided proof-of-concept that retinal imaging might be useful for detecting coronary arterial involvement in young children with KD and it needs further investigation. Nature Publishing Group UK 2019-11-13 /pmc/articles/PMC6853953/ /pubmed/31723195 http://dx.doi.org/10.1038/s41598-019-53220-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lim, Edward Jianyang
Aris, Izzuddin M.
Choo, Jonathan
Wong, Tien Yin
Li, Ling-Jun
Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease
title Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease
title_full Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease
title_fullStr Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease
title_full_unstemmed Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease
title_short Association between Coronary Artery Measurements and Retinal Microvasculature in Children with New Onset of Kawasaki Disease
title_sort association between coronary artery measurements and retinal microvasculature in children with new onset of kawasaki disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853953/
https://www.ncbi.nlm.nih.gov/pubmed/31723195
http://dx.doi.org/10.1038/s41598-019-53220-3
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