ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores

Bacterial ClpP is a highly conserved, cylindrical, self-compartmentalizing serine protease required for maintaining cellular proteostasis. Small molecule acyldepsipeptides (ADEPs) and activators of self-compartmentalized proteases 1 (ACP1s) cause dysregulation and activation of ClpP, leading to bact...

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Detalles Bibliográficos
Autores principales: Mabanglo, Mark F., Leung, Elisa, Vahidi, Siavash, Seraphim, Thiago V., Eger, Bryan T., Bryson, Steve, Bhandari, Vaibhav, Zhou, Jin Lin, Mao, Yu-Qian, Rizzolo, Kamran, Barghash, Marim M., Goodreid, Jordan D., Phanse, Sadhna, Babu, Mohan, Barbosa, Leandro R. S., Ramos, Carlos H. I., Batey, Robert A., Kay, Lewis E., Pai, Emil F., Houry, Walid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853987/
https://www.ncbi.nlm.nih.gov/pubmed/31754640
http://dx.doi.org/10.1038/s42003-019-0656-3

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