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Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease

INTRODUCTION: Neuronal p3-Alcβ peptides are generated from the precursor protein Alcadein β (Alcβ) through cleavage by α- and γ-secretases of the amyloid β (Aβ) protein precursor (APP). To reveal whether p3-Alcβ is involved in Alzheimer's disease (AD) contributes for the development of novel th...

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Detalles Bibliográficos
Autores principales:	Hata, Saori, Omori, Chiori, Kimura, Ayano, Saito, Haruka, Kimura, Nobuyuki, Gupta, Veer, Pedrini, Steve, Hone, Eugene, Chatterjee, Pratishtha, Taddei, Kevin, Kasuga, Kensaku, Ikeuchi, Takeshi, Waragai, Masaaki, Nishimura, Masaki, Hu, Anqi, Nakaya, Tadashi, Meijer, Laurent, Maeda, Masahiro, Yamamoto, Tohru, Masters, Colin L., Rowe, Chris C., Ames, David, Yamamoto, Kazuo, Martins, Ralph N., Gandy, Sam, Suzuki, Toshiharu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854065/ https://www.ncbi.nlm.nih.gov/pubmed/31754625 http://dx.doi.org/10.1016/j.trci.2019.09.015

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