Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway that modulates cellular redox homeostasis via the regeneration of NADPH. G6PD-deficient cells have a reduced ability to induce the innate immune response, thus increasing host susceptibility to path...

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Detalles Bibliográficos
Autores principales: Yen, Wei-Chen, Wu, Yi-Hsuan, Wu, Chih-Ching, Lin, Hsin-Ru, Stern, Arnold, Chen, Shih-Hsiang, Shu, Jwu-Ching, Tsun-Yee Chiu, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854078/
https://www.ncbi.nlm.nih.gov/pubmed/31707353
http://dx.doi.org/10.1016/j.redox.2019.101363

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