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A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network

Network models are applied in numerous domains where data arise from systems of interactions among pairs of actors. Both statistical and mechanistic network models are increasingly capable of capturing various dependencies among these actors. Yet, these dependencies pose statistical challenges for a...

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Autores principales: Chen, Sixing, Onnela, Jukka-Pekka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854093/
https://www.ncbi.nlm.nih.gov/pubmed/31723196
http://dx.doi.org/10.1038/s41598-019-53166-6
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author Chen, Sixing
Onnela, Jukka-Pekka
author_facet Chen, Sixing
Onnela, Jukka-Pekka
author_sort Chen, Sixing
collection PubMed
description Network models are applied in numerous domains where data arise from systems of interactions among pairs of actors. Both statistical and mechanistic network models are increasingly capable of capturing various dependencies among these actors. Yet, these dependencies pose statistical challenges for analyzing such data, especially when the data set comprises only a single observation of one network, often leading to intractable likelihoods regardless of the modeling paradigm and limiting the application of existing statistical methods for networks. We explore a subsampling bootstrap procedure to serve as the basis for goodness of fit and model selection with a single observed network that circumvents the intractability of such likelihoods. Our approach is based on flexible resampling distributions formed from the single observed network, allowing for more nuanced and higher dimensional comparisons than point estimates of quantities of interest. We include worked examples for model selection, with simulation, and assessment of goodness of fit, with duplication-divergence model fits for yeast (S.cerevisiae) protein-protein interaction data from the literature. The proposed approach produces a flexible resampling distribution that can be based on any network statistics of one’s choosing and can be employed for both statistical and mechanistic network models.
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spelling pubmed-68540932019-11-19 A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network Chen, Sixing Onnela, Jukka-Pekka Sci Rep Article Network models are applied in numerous domains where data arise from systems of interactions among pairs of actors. Both statistical and mechanistic network models are increasingly capable of capturing various dependencies among these actors. Yet, these dependencies pose statistical challenges for analyzing such data, especially when the data set comprises only a single observation of one network, often leading to intractable likelihoods regardless of the modeling paradigm and limiting the application of existing statistical methods for networks. We explore a subsampling bootstrap procedure to serve as the basis for goodness of fit and model selection with a single observed network that circumvents the intractability of such likelihoods. Our approach is based on flexible resampling distributions formed from the single observed network, allowing for more nuanced and higher dimensional comparisons than point estimates of quantities of interest. We include worked examples for model selection, with simulation, and assessment of goodness of fit, with duplication-divergence model fits for yeast (S.cerevisiae) protein-protein interaction data from the literature. The proposed approach produces a flexible resampling distribution that can be based on any network statistics of one’s choosing and can be employed for both statistical and mechanistic network models. Nature Publishing Group UK 2019-11-13 /pmc/articles/PMC6854093/ /pubmed/31723196 http://dx.doi.org/10.1038/s41598-019-53166-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Sixing
Onnela, Jukka-Pekka
A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network
title A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network
title_full A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network
title_fullStr A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network
title_full_unstemmed A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network
title_short A Bootstrap Method for Goodness of Fit and Model Selection with a Single Observed Network
title_sort bootstrap method for goodness of fit and model selection with a single observed network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854093/
https://www.ncbi.nlm.nih.gov/pubmed/31723196
http://dx.doi.org/10.1038/s41598-019-53166-6
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