Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model

Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it is unclear whether succinate accumulation contributes to the onset of epilepsy or seizures. We sought to investigate changes in succinate, oxidativ...

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Detalles Bibliográficos
Autores principales: Zhang, Yurong, Zhang, Mengdi, Zhu, Wei, Yu, Jie, Wang, Qiaoyun, Zhang, Jinjin, Cui, Yaru, Pan, Xiaohong, Gao, Xue, Sun, Hongliu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854095/
https://www.ncbi.nlm.nih.gov/pubmed/31707354
http://dx.doi.org/10.1016/j.redox.2019.101365

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