Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes

Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus. In this paper, we found that the same prote...

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Detalles Bibliográficos
Autores principales: Wang, Yujie, Song, Ting, Li, Kaiwu, Jin, Yuan, Yue, Junjie, Ren, Hongguang, Liang, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854240/
https://www.ncbi.nlm.nih.gov/pubmed/31772934
http://dx.doi.org/10.1155/2019/4794910
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author Wang, Yujie
Song, Ting
Li, Kaiwu
Jin, Yuan
Yue, Junjie
Ren, Hongguang
Liang, Long
author_facet Wang, Yujie
Song, Ting
Li, Kaiwu
Jin, Yuan
Yue, Junjie
Ren, Hongguang
Liang, Long
author_sort Wang, Yujie
collection PubMed
description Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus. In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation. By further examining the virus–host protein–protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins. These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes.
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spelling pubmed-68542402019-11-26 Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes Wang, Yujie Song, Ting Li, Kaiwu Jin, Yuan Yue, Junjie Ren, Hongguang Liang, Long Biomed Res Int Research Article Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus. In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation. By further examining the virus–host protein–protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins. These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes. Hindawi 2019-10-22 /pmc/articles/PMC6854240/ /pubmed/31772934 http://dx.doi.org/10.1155/2019/4794910 Text en Copyright © 2019 Yujie Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yujie
Song, Ting
Li, Kaiwu
Jin, Yuan
Yue, Junjie
Ren, Hongguang
Liang, Long
Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
title Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
title_full Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
title_fullStr Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
title_full_unstemmed Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
title_short Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
title_sort different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854240/
https://www.ncbi.nlm.nih.gov/pubmed/31772934
http://dx.doi.org/10.1155/2019/4794910
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