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EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways

Diabetes mellitus is characterized by pancreatic β cell dysfunction. Previous studies have indicated that epidermal growth factor (EGF) and microRNA-124a (miR-124a) play opposite roles in insulin biosynthesis and secretion by beta cells. However, the underlying mechanisms remain poorly understood. I...

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Detalles Bibliográficos
Autores principales:	Yang, Lin, Zhu, Yuansen, Kong, Delin, Gong, Jiawei, Yu, Wen, Liang, Yang, Nie, Yuzhe, Teng, Chun-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854373/ https://www.ncbi.nlm.nih.gov/pubmed/31754329 http://dx.doi.org/10.7150/ijbs.34985

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