Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer

CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM fami...

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Autores principales: Wu, Keheng, Li, Xiaoman, Gu, Huadi, Yang, Qiao, Liu, Yingying, Wang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854381/
https://www.ncbi.nlm.nih.gov/pubmed/31754330
http://dx.doi.org/10.7150/ijbs.33733
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author Wu, Keheng
Li, Xiaoman
Gu, Huadi
Yang, Qiao
Liu, Yingying
Wang, Liang
author_facet Wu, Keheng
Li, Xiaoman
Gu, Huadi
Yang, Qiao
Liu, Yingying
Wang, Liang
author_sort Wu, Keheng
collection PubMed
description CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an important role in the hematopoiesis system, the immune system, the cardiovascular system and the male reproductive system. Recent in-depth research has also revealed that CMTM is closely associated with the genesis, development and metastasis of tumors, displaying opposing activities in diverse human tumors. In this review, we discuss the structural and functional characteristics of the CMTM family and summarize latest research findings of the relationship between several CMTM members and non-small cell lung cancer.
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spelling pubmed-68543812019-11-21 Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer Wu, Keheng Li, Xiaoman Gu, Huadi Yang, Qiao Liu, Yingying Wang, Liang Int J Biol Sci Review CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an important role in the hematopoiesis system, the immune system, the cardiovascular system and the male reproductive system. Recent in-depth research has also revealed that CMTM is closely associated with the genesis, development and metastasis of tumors, displaying opposing activities in diverse human tumors. In this review, we discuss the structural and functional characteristics of the CMTM family and summarize latest research findings of the relationship between several CMTM members and non-small cell lung cancer. Ivyspring International Publisher 2019-09-07 /pmc/articles/PMC6854381/ /pubmed/31754330 http://dx.doi.org/10.7150/ijbs.33733 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wu, Keheng
Li, Xiaoman
Gu, Huadi
Yang, Qiao
Liu, Yingying
Wang, Liang
Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
title Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
title_full Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
title_fullStr Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
title_full_unstemmed Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
title_short Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
title_sort research advances in cklf-like marvel transmembrane domain-containing family in non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854381/
https://www.ncbi.nlm.nih.gov/pubmed/31754330
http://dx.doi.org/10.7150/ijbs.33733
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