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Prediction of Drug Permeability Using In Vitro Blood–Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells

The strong barrier function of the blood–brain barrier (BBB) protects the central nervous system (CNS) from xenobiotic substances, while the expression of selective transporters controls the transportation of nutrients between the blood and brain. As a result, the delivery of drugs to the CNS and pr...

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Detalles Bibliográficos
Autores principales:	Ohshima, Makiko, Kamei, Shota, Fushimi, Hideo, Mima, Shinji, Yamada, Tadanori, Yamamoto, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2019
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854432/ https://www.ncbi.nlm.nih.gov/pubmed/31737437 http://dx.doi.org/10.1089/biores.2019.0026

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