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Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma
BACKGROUND: Numerous studies have investigated the association between hormone receptor expression and clinical outcome in ovarian carcinoma (OC); however, these have largely focussed on serous OCs, with few studies reporting specifically on endometrioid OCs (EnOC). Where analyses have been stratifi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854467/ https://www.ncbi.nlm.nih.gov/pubmed/31495455 http://dx.doi.org/10.1016/j.ygyno.2019.09.001 |
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author | Hollis, Robert L. Stanley, Barbara Iida, Yasushi Thomson, John Churchman, Michael Rye, Tzyvia Mackean, Melanie Nussey, Fiona Gourley, Charlie Herrington, C. Simon |
author_facet | Hollis, Robert L. Stanley, Barbara Iida, Yasushi Thomson, John Churchman, Michael Rye, Tzyvia Mackean, Melanie Nussey, Fiona Gourley, Charlie Herrington, C. Simon |
author_sort | Hollis, Robert L. |
collection | PubMed |
description | BACKGROUND: Numerous studies have investigated the association between hormone receptor expression and clinical outcome in ovarian carcinoma (OC); however, these have largely focussed on serous OCs, with few studies reporting specifically on endometrioid OCs (EnOC). Where analyses have been stratified by histotype, expression has been assessed using the percentage of positive tumor cells, without accounting for nuclear expression intensity. METHODS: Here we assess the expression levels of progesterone receptor (PR), estrogen receptor alpha (ER) and androgen receptor (AR) using histoscore – a nuclear scoring method incorporating both proportion of positive cells and the intensity of nuclear staining – across a cohort of 107 WT1 negative EnOCs. RESULTS: Hierarchical clustering by PR, ER and AR histoscores identified four EnOC subgroups (PR+/ER+, PR+/ER−, PR−/ER+ and PR−/ER−). EnOC patients in the PR+/ER+ and PR+/ER− groups displayed favorable outcome (multivariable HR for disease-specific survival 0.05 [0.01–0.35] and 0.05 [0.00–0.51]) compared to the PR−/ER+ group. Ten-year survival for stage II PR(high) and PR(low) cases was 94.1% and 42.4%. ER(high) EnOC patients (PR+/ER+, PR−/ER+) had higher body mass index compared to ER(low) cases (P = 0.015) and high grade serous OC patients (P < 0.001). CONCLUSION: These data demonstrate that endometrioid OC cases with high PR expression display markedly favorable outcome. Stage II EnOCs with high PR expression represent potential candidates for de-escalation of first-line therapy. Future work should seek to characterise the sensitivity of PR and ER positive EnOCs to endocrine therapy. |
format | Online Article Text |
id | pubmed-6854467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68544672019-11-20 Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma Hollis, Robert L. Stanley, Barbara Iida, Yasushi Thomson, John Churchman, Michael Rye, Tzyvia Mackean, Melanie Nussey, Fiona Gourley, Charlie Herrington, C. Simon Gynecol Oncol Article BACKGROUND: Numerous studies have investigated the association between hormone receptor expression and clinical outcome in ovarian carcinoma (OC); however, these have largely focussed on serous OCs, with few studies reporting specifically on endometrioid OCs (EnOC). Where analyses have been stratified by histotype, expression has been assessed using the percentage of positive tumor cells, without accounting for nuclear expression intensity. METHODS: Here we assess the expression levels of progesterone receptor (PR), estrogen receptor alpha (ER) and androgen receptor (AR) using histoscore – a nuclear scoring method incorporating both proportion of positive cells and the intensity of nuclear staining – across a cohort of 107 WT1 negative EnOCs. RESULTS: Hierarchical clustering by PR, ER and AR histoscores identified four EnOC subgroups (PR+/ER+, PR+/ER−, PR−/ER+ and PR−/ER−). EnOC patients in the PR+/ER+ and PR+/ER− groups displayed favorable outcome (multivariable HR for disease-specific survival 0.05 [0.01–0.35] and 0.05 [0.00–0.51]) compared to the PR−/ER+ group. Ten-year survival for stage II PR(high) and PR(low) cases was 94.1% and 42.4%. ER(high) EnOC patients (PR+/ER+, PR−/ER+) had higher body mass index compared to ER(low) cases (P = 0.015) and high grade serous OC patients (P < 0.001). CONCLUSION: These data demonstrate that endometrioid OC cases with high PR expression display markedly favorable outcome. Stage II EnOCs with high PR expression represent potential candidates for de-escalation of first-line therapy. Future work should seek to characterise the sensitivity of PR and ER positive EnOCs to endocrine therapy. Academic Press 2019-11 /pmc/articles/PMC6854467/ /pubmed/31495455 http://dx.doi.org/10.1016/j.ygyno.2019.09.001 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hollis, Robert L. Stanley, Barbara Iida, Yasushi Thomson, John Churchman, Michael Rye, Tzyvia Mackean, Melanie Nussey, Fiona Gourley, Charlie Herrington, C. Simon Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
title | Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
title_full | Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
title_fullStr | Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
title_full_unstemmed | Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
title_short | Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
title_sort | hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854467/ https://www.ncbi.nlm.nih.gov/pubmed/31495455 http://dx.doi.org/10.1016/j.ygyno.2019.09.001 |
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