Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

[Image: see text] In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the...

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Detalles Bibliográficos
Autores principales: Magnin, Geraldine, Bissel, Philippe, Council-Troche, Roberto McAlister, Zhou, Zhiguo, Ehrich, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854557/
https://www.ncbi.nlm.nih.gov/pubmed/31737826
http://dx.doi.org/10.1021/acsomega.9b02587
Descripción
Sumario:[Image: see text] In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M(–1) indicates that this binding was not covalent.

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