Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

[Image: see text] In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the...

Descripción completa

Detalles Bibliográficos
Autores principales: Magnin, Geraldine, Bissel, Philippe, Council-Troche, Roberto McAlister, Zhou, Zhiguo, Ehrich, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854557/
https://www.ncbi.nlm.nih.gov/pubmed/31737826
http://dx.doi.org/10.1021/acsomega.9b02587
_version_ 1783470230942515200
author Magnin, Geraldine
Bissel, Philippe
Council-Troche, Roberto McAlister
Zhou, Zhiguo
Ehrich, Marion
author_facet Magnin, Geraldine
Bissel, Philippe
Council-Troche, Roberto McAlister
Zhou, Zhiguo
Ehrich, Marion
author_sort Magnin, Geraldine
collection PubMed
description [Image: see text] In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M(–1) indicates that this binding was not covalent.
format Online
Article
Text
id pubmed-6854557
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-68545572019-11-15 Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes Magnin, Geraldine Bissel, Philippe Council-Troche, Roberto McAlister Zhou, Zhiguo Ehrich, Marion ACS Omega [Image: see text] In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M(–1) indicates that this binding was not covalent. American Chemical Society 2019-10-28 /pmc/articles/PMC6854557/ /pubmed/31737826 http://dx.doi.org/10.1021/acsomega.9b02587 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Magnin, Geraldine
Bissel, Philippe
Council-Troche, Roberto McAlister
Zhou, Zhiguo
Ehrich, Marion
Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
title Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
title_full Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
title_fullStr Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
title_full_unstemmed Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
title_short Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
title_sort studies exploring the interaction of the organophosphorus compound paraoxon with fullerenes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854557/
https://www.ncbi.nlm.nih.gov/pubmed/31737826
http://dx.doi.org/10.1021/acsomega.9b02587
work_keys_str_mv AT magningeraldine studiesexploringtheinteractionoftheorganophosphoruscompoundparaoxonwithfullerenes
AT bisselphilippe studiesexploringtheinteractionoftheorganophosphoruscompoundparaoxonwithfullerenes
AT counciltrocherobertomcalister studiesexploringtheinteractionoftheorganophosphoruscompoundparaoxonwithfullerenes
AT zhouzhiguo studiesexploringtheinteractionoftheorganophosphoruscompoundparaoxonwithfullerenes
AT ehrichmarion studiesexploringtheinteractionoftheorganophosphoruscompoundparaoxonwithfullerenes

Ejemplares similares