Enhanced Bone Remodeling Effects of Low-Modulus Ti–5Zr–3Sn–5Mo–25Nb Alloy Implanted in the Mandible of Beagle Dogs under Delayed Loading

[Image: see text] Titanium (Ti) and its alloys are widely used in the dental and prosthetic implant fields due to their favorable biocompatibility. In this study, porous surface coatings incorporated with nanoscale hydroxyapatite particles on the surface of Ti and Ti–5Zr–3Sn–5Mo–25Nb (TLM) alloy were fabricated by microarc oxidation followed by hydrothermal treatment; the surface roughness and hydrophilicity were obviously enhanced by the surface modification procedure. In vivo, four adult male beagle dogs were selected for an implantation procedure and restored with full metal crowns after healing for 3 months. The bone responses were evaluated via histomorphological observation. Raman spectral analysis and nanoindentation experiments were used to quantitatively and qualitatively estimate the characteristics of the bone formed around the implants. Compared to the Ti group, the TLM titanium alloy group showed a significant increase in the percentage of bone–implant interface contact, bone inside the thread, mineralization, crystallinity, modulus of elasticity, and hardness of the integrated bone after delayed loading in the TLM group. Therefore, the TLM titanium alloy is considered a candidate implant material with desirable biomechanical compatibility, especially under applied stress.