mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?

BACKGROUND: Animal studies suggested that blocking the activation of the mammalian target of rapamycin (mTOR) pathway might be effective to treat cardiac hypertrophy in LEOPARD syndrome (LS) caused by PTPN11 mutations. RESULTS: In the present study, mTOR pathway activity was examined in human myocar...

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Detalles Bibliográficos
Autores principales: Cui, Hao, Song, Lei, Zhu, Changsheng, Zhang, Ce, Tang, Bing, Wang, Shengwei, Wu, Guixin, Zou, Yubao, Huang, Xiaohong, Hui, Rutai, Wang, Shuiyun, Wang, Jizheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854668/
https://www.ncbi.nlm.nih.gov/pubmed/31722741
http://dx.doi.org/10.1186/s13023-019-1204-4

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