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Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli

BACKGROUND: Filamentous fungi produce a vast amount of bioactive secondary metabolites (SMs) synthesized by e.g. hybrid polyketide synthase-nonribosomal peptide synthetase enzymes (PKS-NRPS; NRPS-PKS). While their domain structure suggests a common ancestor with other SM proteins, their evolutionary...

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Detalles Bibliográficos
Autores principales:	Theobald, Sebastian, Vesth, Tammi C., Andersen, Mikael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854747/ https://www.ncbi.nlm.nih.gov/pubmed/31722662 http://dx.doi.org/10.1186/s12864-019-6114-2

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