Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles

[Image: see text] MeOTf-triggered annulation of N-(2-cyanoaryl)indoles to provide indolo[1,2-a]indol-10-imines and the corresponding indolo[1,2-a]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yiel...

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Autores principales: Zou, Song, Liu, Yu, Xi, Chanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854827/
https://www.ncbi.nlm.nih.gov/pubmed/31737835
http://dx.doi.org/10.1021/acsomega.9b02679
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author Zou, Song
Liu, Yu
Xi, Chanjuan
author_facet Zou, Song
Liu, Yu
Xi, Chanjuan
author_sort Zou, Song
collection PubMed
description [Image: see text] MeOTf-triggered annulation of N-(2-cyanoaryl)indoles to provide indolo[1,2-a]indol-10-imines and the corresponding indolo[1,2-a]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale.
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spelling pubmed-68548272019-11-15 Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles Zou, Song Liu, Yu Xi, Chanjuan ACS Omega [Image: see text] MeOTf-triggered annulation of N-(2-cyanoaryl)indoles to provide indolo[1,2-a]indol-10-imines and the corresponding indolo[1,2-a]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale. American Chemical Society 2019-10-29 /pmc/articles/PMC6854827/ /pubmed/31737835 http://dx.doi.org/10.1021/acsomega.9b02679 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zou, Song
Liu, Yu
Xi, Chanjuan
Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
title Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
title_full Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
title_fullStr Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
title_full_unstemmed Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
title_short Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
title_sort concise and efficient synthesis of indole–indolone scaffolds through meotf-induced annulation of n-(2-cyanoaryl)indoles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854827/
https://www.ncbi.nlm.nih.gov/pubmed/31737835
http://dx.doi.org/10.1021/acsomega.9b02679
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AT xichanjuan conciseandefficientsynthesisofindoleindolonescaffoldsthroughmeotfinducedannulationofn2cyanoarylindoles

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