Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes

[Image: see text] A phthaloyl-protected aminooxymethyl-C-2′-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded ol...

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Autores principales: Maity, Sajal Kumar, Lönnberg, Tuomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854833/
https://www.ncbi.nlm.nih.gov/pubmed/31737842
http://dx.doi.org/10.1021/acsomega.9b02804
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author Maity, Sajal Kumar
Lönnberg, Tuomas A.
author_facet Maity, Sajal Kumar
Lönnberg, Tuomas A.
author_sort Maity, Sajal Kumar
collection PubMed
description [Image: see text] A phthaloyl-protected aminooxymethyl-C-2′-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.
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spelling pubmed-68548332019-11-15 Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes Maity, Sajal Kumar Lönnberg, Tuomas A. ACS Omega [Image: see text] A phthaloyl-protected aminooxymethyl-C-2′-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles. American Chemical Society 2019-11-01 /pmc/articles/PMC6854833/ /pubmed/31737842 http://dx.doi.org/10.1021/acsomega.9b02804 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Maity, Sajal Kumar
Lönnberg, Tuomas A.
Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
title Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
title_full Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
title_fullStr Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
title_full_unstemmed Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
title_short Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
title_sort synthesis of organometallic oligonucleotides through oximation with metalated benzaldehydes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854833/
https://www.ncbi.nlm.nih.gov/pubmed/31737842
http://dx.doi.org/10.1021/acsomega.9b02804
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AT lonnbergtuomasa synthesisoforganometallicoligonucleotidesthroughoximationwithmetalatedbenzaldehydes

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