Cargando…

Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury

High concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20...

Descripción completa

Detalles Bibliográficos
Autores principales: Czuczejko, Jolanta, Mila-Kierzenkowska, Celestyna, Szewczyk-Golec, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854929/
https://www.ncbi.nlm.nih.gov/pubmed/31772928
http://dx.doi.org/10.1155/2019/5850787
_version_ 1783470312281604096
author Czuczejko, Jolanta
Mila-Kierzenkowska, Celestyna
Szewczyk-Golec, Karolina
author_facet Czuczejko, Jolanta
Mila-Kierzenkowska, Celestyna
Szewczyk-Golec, Karolina
author_sort Czuczejko, Jolanta
collection PubMed
description High concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20 healthy volunteers and 52 patients were included in the study. The patients were divided into three groups: group I (acute viral hepatitis B or C), group II (chronic hepatitis B or C), and group III (chronic liver disease or cirrhosis with different etiologies). The concentration of α-GST and the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in all examined groups. α-GST, ALT, and AST were statistically higher in all patient groups than in the control group. Statistically higher values of all assessed parameters were observed in group I compared with remaining patients. Statistically higher activities of ALT and AST are observed in group III compared with group II. Significant positive correlations were noted between α-GST and ALT/AST in groups I and III. The results indicate that the assay of α-GST in combination with the other conventional markers may be found as a confirmatory test for hepatocellular damage.
format Online
Article
Text
id pubmed-6854929
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-68549292019-11-26 Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury Czuczejko, Jolanta Mila-Kierzenkowska, Celestyna Szewczyk-Golec, Karolina Can J Gastroenterol Hepatol Research Article High concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20 healthy volunteers and 52 patients were included in the study. The patients were divided into three groups: group I (acute viral hepatitis B or C), group II (chronic hepatitis B or C), and group III (chronic liver disease or cirrhosis with different etiologies). The concentration of α-GST and the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in all examined groups. α-GST, ALT, and AST were statistically higher in all patient groups than in the control group. Statistically higher values of all assessed parameters were observed in group I compared with remaining patients. Statistically higher activities of ALT and AST are observed in group III compared with group II. Significant positive correlations were noted between α-GST and ALT/AST in groups I and III. The results indicate that the assay of α-GST in combination with the other conventional markers may be found as a confirmatory test for hepatocellular damage. Hindawi 2019-10-20 /pmc/articles/PMC6854929/ /pubmed/31772928 http://dx.doi.org/10.1155/2019/5850787 Text en Copyright © 2019 Jolanta Czuczejko et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Czuczejko, Jolanta
Mila-Kierzenkowska, Celestyna
Szewczyk-Golec, Karolina
Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
title Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
title_full Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
title_fullStr Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
title_full_unstemmed Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
title_short Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
title_sort plasma α-glutathione s-transferase evaluation in patients with acute and chronic liver injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854929/
https://www.ncbi.nlm.nih.gov/pubmed/31772928
http://dx.doi.org/10.1155/2019/5850787
work_keys_str_mv AT czuczejkojolanta plasmaaglutathionestransferaseevaluationinpatientswithacuteandchronicliverinjury
AT milakierzenkowskacelestyna plasmaaglutathionestransferaseevaluationinpatientswithacuteandchronicliverinjury
AT szewczykgoleckarolina plasmaaglutathionestransferaseevaluationinpatientswithacuteandchronicliverinjury