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Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection
BACKGROUND: Mutations in the progesterone receptor (PR) gene, PROGINS, have been studied in relation to hepatitis E virus (HEV) infection. Patients with the PROGINS gene may develop a worse clinical course of hepatitis E. The aim of our study was to evaluate the influence of PROGINS on the susceptib...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854998/ https://www.ncbi.nlm.nih.gov/pubmed/31787965 http://dx.doi.org/10.3389/fmicb.2019.02617 |
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author | López-López, Pedro Rivero-Juarez, Antonio Frias, Mario Machuca, Isabel Caballero-Gómez, Javier Olivas, Israel Camacho, Angela Risalde, María de los Angeles García-Bocanegra, Ignacio Rivero, Antonio |
author_facet | López-López, Pedro Rivero-Juarez, Antonio Frias, Mario Machuca, Isabel Caballero-Gómez, Javier Olivas, Israel Camacho, Angela Risalde, María de los Angeles García-Bocanegra, Ignacio Rivero, Antonio |
author_sort | López-López, Pedro |
collection | PubMed |
description | BACKGROUND: Mutations in the progesterone receptor (PR) gene, PROGINS, have been studied in relation to hepatitis E virus (HEV) infection. Patients with the PROGINS gene may develop a worse clinical course of hepatitis E. The aim of our study was to evaluate the influence of PROGINS on the susceptibility to and the clinical course of HEV infection in HIV patients. METHODS: This study included patients with HIV who were evaluated in previous prospective studies for the prevalence and incidence of HEV. The following three groups of patients were studied: (i) never infected, (ii) past infections, and (iii) recently infected. We determined the PR genotype to evaluate the proportion of patients who were homozygous for PROGINS according to HEV infection. We also compared the proportion of PROGINS carriers with a recent HEV infection according to their symptomatology. RESULTS: In this study, 311 patients infected with HIV were included. Of those patients, 198 were homozygous wild type (63.7%), 91 were heterozygous (29.3%), and 22 were homozygous PROGINS (7.1%). We found that the homozygous PROGINS genotype in women was associated with a lower HEV seroprevalence. In addition, in patients with a recent HEV infection, none of those homozygous for PROGINS presented symptoms. CONCLUSION: The PROGINS mutation plays a protective role against HEV infection and is associated with subclinical infection in HIV-infected patients, particularly women. |
format | Online Article Text |
id | pubmed-6854998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68549982019-11-29 Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection López-López, Pedro Rivero-Juarez, Antonio Frias, Mario Machuca, Isabel Caballero-Gómez, Javier Olivas, Israel Camacho, Angela Risalde, María de los Angeles García-Bocanegra, Ignacio Rivero, Antonio Front Microbiol Microbiology BACKGROUND: Mutations in the progesterone receptor (PR) gene, PROGINS, have been studied in relation to hepatitis E virus (HEV) infection. Patients with the PROGINS gene may develop a worse clinical course of hepatitis E. The aim of our study was to evaluate the influence of PROGINS on the susceptibility to and the clinical course of HEV infection in HIV patients. METHODS: This study included patients with HIV who were evaluated in previous prospective studies for the prevalence and incidence of HEV. The following three groups of patients were studied: (i) never infected, (ii) past infections, and (iii) recently infected. We determined the PR genotype to evaluate the proportion of patients who were homozygous for PROGINS according to HEV infection. We also compared the proportion of PROGINS carriers with a recent HEV infection according to their symptomatology. RESULTS: In this study, 311 patients infected with HIV were included. Of those patients, 198 were homozygous wild type (63.7%), 91 were heterozygous (29.3%), and 22 were homozygous PROGINS (7.1%). We found that the homozygous PROGINS genotype in women was associated with a lower HEV seroprevalence. In addition, in patients with a recent HEV infection, none of those homozygous for PROGINS presented symptoms. CONCLUSION: The PROGINS mutation plays a protective role against HEV infection and is associated with subclinical infection in HIV-infected patients, particularly women. Frontiers Media S.A. 2019-11-07 /pmc/articles/PMC6854998/ /pubmed/31787965 http://dx.doi.org/10.3389/fmicb.2019.02617 Text en Copyright © 2019 López-López, Rivero-Juarez, Frias, Machuca, Caballero-Gómez, Olivas, Camacho, Risalde, García-Bocanegra and Rivero. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology López-López, Pedro Rivero-Juarez, Antonio Frias, Mario Machuca, Isabel Caballero-Gómez, Javier Olivas, Israel Camacho, Angela Risalde, María de los Angeles García-Bocanegra, Ignacio Rivero, Antonio Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection |
title | Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection |
title_full | Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection |
title_fullStr | Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection |
title_full_unstemmed | Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection |
title_short | Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection |
title_sort | mutations in the progesterone receptor (progins) may reduce the symptoms of acute hepatitis e and protect against infection |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854998/ https://www.ncbi.nlm.nih.gov/pubmed/31787965 http://dx.doi.org/10.3389/fmicb.2019.02617 |
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