Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab

Rituximab (RTX) is a chimeric B-cell-depleting monoclonal antibody against CD-20 positive cells that has been approved for the induction and maintenance of granulomatosis with polyangiitis (GPA). Reports have identified RTX to cause drug-related psoriasis. Many theories of underlying pathways have b...

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Autores principales: Alahmari, Hana S., Alhowaish, Nasser Y., Omair, Mohammed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855024/
https://www.ncbi.nlm.nih.gov/pubmed/31781463
http://dx.doi.org/10.1155/2019/5450863
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author Alahmari, Hana S.
Alhowaish, Nasser Y.
Omair, Mohammed A.
author_facet Alahmari, Hana S.
Alhowaish, Nasser Y.
Omair, Mohammed A.
author_sort Alahmari, Hana S.
collection PubMed
description Rituximab (RTX) is a chimeric B-cell-depleting monoclonal antibody against CD-20 positive cells that has been approved for the induction and maintenance of granulomatosis with polyangiitis (GPA). Reports have identified RTX to cause drug-related psoriasis. Many theories of underlying pathways have been proposed. However, further workup around the mechanism and treatment is required. Here, we present a 38-year-old woman known to have GPA that developed drug-related psoriasis that was successfully treated with treatment discontinuation and starting adalimumab along with a literature review.
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spelling pubmed-68550242019-11-28 Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab Alahmari, Hana S. Alhowaish, Nasser Y. Omair, Mohammed A. Case Rep Rheumatol Case Report Rituximab (RTX) is a chimeric B-cell-depleting monoclonal antibody against CD-20 positive cells that has been approved for the induction and maintenance of granulomatosis with polyangiitis (GPA). Reports have identified RTX to cause drug-related psoriasis. Many theories of underlying pathways have been proposed. However, further workup around the mechanism and treatment is required. Here, we present a 38-year-old woman known to have GPA that developed drug-related psoriasis that was successfully treated with treatment discontinuation and starting adalimumab along with a literature review. Hindawi 2019-10-17 /pmc/articles/PMC6855024/ /pubmed/31781463 http://dx.doi.org/10.1155/2019/5450863 Text en Copyright © 2019 Hana S. Alahmari et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alahmari, Hana S.
Alhowaish, Nasser Y.
Omair, Mohammed A.
Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab
title Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab
title_full Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab
title_fullStr Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab
title_full_unstemmed Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab
title_short Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab
title_sort rituximab-induced psoriasis in a patient with granulomatosis with polyangitis treated with adalimumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855024/
https://www.ncbi.nlm.nih.gov/pubmed/31781463
http://dx.doi.org/10.1155/2019/5450863
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AT omairmohammeda rituximabinducedpsoriasisinapatientwithgranulomatosiswithpolyangitistreatedwithadalimumab

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