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Diminished food-related motivation in adult rats treated with methamphetamine during adolescence

Drug use among adolescents continues to be an area of concern because of the possibility of long-lasting physical and mental changes. The aim of this study was to determine whether methamphetamine exposure during adolescence results in long-lasting neurobehavioral alterations in adulthood. Sprague–D...

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Autores principales: Lee, Jung Ho, Kim, Dong Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855325/
https://www.ncbi.nlm.nih.gov/pubmed/31568209
http://dx.doi.org/10.1097/WNR.0000000000001325
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author Lee, Jung Ho
Kim, Dong Goo
author_facet Lee, Jung Ho
Kim, Dong Goo
author_sort Lee, Jung Ho
collection PubMed
description Drug use among adolescents continues to be an area of concern because of the possibility of long-lasting physical and mental changes. The aim of this study was to determine whether methamphetamine exposure during adolescence results in long-lasting neurobehavioral alterations in adulthood. Sprague–Dawley rats were injected with methamphetamine (4 mg/kg/day) during postnatal days 28–37. Once rats reached postnatal days 150, they were placed in standard operant chambers, where they were trained to respond to a lever for sucrose pellets, the experimental reinforcement. Methamphetamine exposure during adolescence did not result in a noteworthy impairment in the development of the correct lever touch response in the autoshaped learning test with 4 seconds delayed reinforcement. These rats were also tested for the motivation to obtain sucrose pellets under a progressive ratio schedule of the reinforcement on postnatal days 170. Decreased lever-pressing response was noted in male rats exposed to methamphetamine during adolescence, but not in female rats. These results indicate that methamphetamine exposure during adolescence results in a decrease in the motivation for a natural reinforcer later in adulthood, particularly in male rats. From our data, we suggest that male brains are less capable of facilitating recovery than female brains after methamphetamine-induced perturbation of brain function during the adolescent period.
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spelling pubmed-68553252020-01-23 Diminished food-related motivation in adult rats treated with methamphetamine during adolescence Lee, Jung Ho Kim, Dong Goo Neuroreport Degeneration and Repair Drug use among adolescents continues to be an area of concern because of the possibility of long-lasting physical and mental changes. The aim of this study was to determine whether methamphetamine exposure during adolescence results in long-lasting neurobehavioral alterations in adulthood. Sprague–Dawley rats were injected with methamphetamine (4 mg/kg/day) during postnatal days 28–37. Once rats reached postnatal days 150, they were placed in standard operant chambers, where they were trained to respond to a lever for sucrose pellets, the experimental reinforcement. Methamphetamine exposure during adolescence did not result in a noteworthy impairment in the development of the correct lever touch response in the autoshaped learning test with 4 seconds delayed reinforcement. These rats were also tested for the motivation to obtain sucrose pellets under a progressive ratio schedule of the reinforcement on postnatal days 170. Decreased lever-pressing response was noted in male rats exposed to methamphetamine during adolescence, but not in female rats. These results indicate that methamphetamine exposure during adolescence results in a decrease in the motivation for a natural reinforcer later in adulthood, particularly in male rats. From our data, we suggest that male brains are less capable of facilitating recovery than female brains after methamphetamine-induced perturbation of brain function during the adolescent period. Lippincott Williams & Wilkins 2019-12-10 2019-08-19 /pmc/articles/PMC6855325/ /pubmed/31568209 http://dx.doi.org/10.1097/WNR.0000000000001325 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Degeneration and Repair
Lee, Jung Ho
Kim, Dong Goo
Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
title Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
title_full Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
title_fullStr Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
title_full_unstemmed Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
title_short Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
title_sort diminished food-related motivation in adult rats treated with methamphetamine during adolescence
topic Degeneration and Repair
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855325/
https://www.ncbi.nlm.nih.gov/pubmed/31568209
http://dx.doi.org/10.1097/WNR.0000000000001325
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