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A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional regulators. The tri-member Hypoxia Inducible Factor (HIF) family of DNA-binding transcription factors include HIF-2, which is activated unde...

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Detalles Bibliográficos
Autores principales:	Nagati, Jason S., Xu, Min, Garcia, Trent, Comerford, Sarah A., Hammer, Robert E., Garcia, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855420/ https://www.ncbi.nlm.nih.gov/pubmed/31725783 http://dx.doi.org/10.1371/journal.pone.0225105

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