Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represents a spectrum of rare but severe mucocutaneous drug reactions. Gastrointestinal involvement of SJS/TEN is associated with high morbidity and mortality and often presents 2–3 weeks after the initial appearance of skin lesions. Th...

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Autores principales: Claytor, Jennifer D., Herfarth, Hans H., Weaver, Kimberly N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855542/
https://www.ncbi.nlm.nih.gov/pubmed/31832469
http://dx.doi.org/10.14309/crj.0000000000000242
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author Claytor, Jennifer D.
Herfarth, Hans H.
Weaver, Kimberly N.
author_facet Claytor, Jennifer D.
Herfarth, Hans H.
Weaver, Kimberly N.
author_sort Claytor, Jennifer D.
collection PubMed
description Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represents a spectrum of rare but severe mucocutaneous drug reactions. Gastrointestinal involvement of SJS/TEN is associated with high morbidity and mortality and often presents 2–3 weeks after the initial appearance of skin lesions. There are no evidence-based treatment algorithms for the management of SJS/TEN. We report a case of life-threatening gastrointestinal bleeding from colonic involvement of SJS/TEN and discuss potential therapeutic options.
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spelling pubmed-68555422019-12-12 Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding Claytor, Jennifer D. Herfarth, Hans H. Weaver, Kimberly N. ACG Case Rep J Case Report Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represents a spectrum of rare but severe mucocutaneous drug reactions. Gastrointestinal involvement of SJS/TEN is associated with high morbidity and mortality and often presents 2–3 weeks after the initial appearance of skin lesions. There are no evidence-based treatment algorithms for the management of SJS/TEN. We report a case of life-threatening gastrointestinal bleeding from colonic involvement of SJS/TEN and discuss potential therapeutic options. Wolters Kluwer 2019-10-17 /pmc/articles/PMC6855542/ /pubmed/31832469 http://dx.doi.org/10.14309/crj.0000000000000242 Text en © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Claytor, Jennifer D.
Herfarth, Hans H.
Weaver, Kimberly N.
Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding
title Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding
title_full Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding
title_fullStr Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding
title_full_unstemmed Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding
title_short Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding
title_sort colonic involvement of stevens-johnson syndrome/toxic epidermal necrolysis: a rare cause of gastrointestinal bleeding
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855542/
https://www.ncbi.nlm.nih.gov/pubmed/31832469
http://dx.doi.org/10.14309/crj.0000000000000242
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