Marginal zone lymphoma causing accelerated progression of chronic kidney disease

A 75-year-old man with stage IV chronic kidney disease due to type 2 diabetes mellitus, presented with increasing proteinuria and rapidly declining renal function despite excellent glycaemic control. Investigations organised to assess his suitability for renal transplantation included an abdominal C...

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Autores principales: Samarasinghe, Amali, Wong, Daniel, Cull, Gavin, Chakera, Aron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855851/
https://www.ncbi.nlm.nih.gov/pubmed/31712228
http://dx.doi.org/10.1136/bcr-2019-230270
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author Samarasinghe, Amali
Wong, Daniel
Cull, Gavin
Chakera, Aron
author_facet Samarasinghe, Amali
Wong, Daniel
Cull, Gavin
Chakera, Aron
author_sort Samarasinghe, Amali
collection PubMed
description A 75-year-old man with stage IV chronic kidney disease due to type 2 diabetes mellitus, presented with increasing proteinuria and rapidly declining renal function despite excellent glycaemic control. Investigations organised to assess his suitability for renal transplantation included an abdominal CT scan, which revealed extensive intra-abdominal lymphadenopathy. A (17)fluorodeoxyglucose (FDG)-positron emission tomography scan to further characterise the lymphadenopathy demonstrated activity in the lymph nodes, as well as both kidneys. Following a lymph node biopsy and flow cytometry he was diagnosed with a marginal zone lymphoma. A subsequent kidney biopsy confirmed lymphomatous infiltration of the kidney. Marginal zone lymphoma is an uncommon type of non-Hodgkin's lymphoma, and renal involvement is rare. This case highlights the importance of considering alternative diagnoses when there is deviation from the expected clinical trajectory and the importance of liaising with colleagues in other disciplines to enable an accurate diagnosis to be made.
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spelling pubmed-68558512019-12-03 Marginal zone lymphoma causing accelerated progression of chronic kidney disease Samarasinghe, Amali Wong, Daniel Cull, Gavin Chakera, Aron BMJ Case Rep Unusual Presentation of More Common Disease/Injury A 75-year-old man with stage IV chronic kidney disease due to type 2 diabetes mellitus, presented with increasing proteinuria and rapidly declining renal function despite excellent glycaemic control. Investigations organised to assess his suitability for renal transplantation included an abdominal CT scan, which revealed extensive intra-abdominal lymphadenopathy. A (17)fluorodeoxyglucose (FDG)-positron emission tomography scan to further characterise the lymphadenopathy demonstrated activity in the lymph nodes, as well as both kidneys. Following a lymph node biopsy and flow cytometry he was diagnosed with a marginal zone lymphoma. A subsequent kidney biopsy confirmed lymphomatous infiltration of the kidney. Marginal zone lymphoma is an uncommon type of non-Hodgkin's lymphoma, and renal involvement is rare. This case highlights the importance of considering alternative diagnoses when there is deviation from the expected clinical trajectory and the importance of liaising with colleagues in other disciplines to enable an accurate diagnosis to be made. BMJ Publishing Group 2019-11-10 /pmc/articles/PMC6855851/ /pubmed/31712228 http://dx.doi.org/10.1136/bcr-2019-230270 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Unusual Presentation of More Common Disease/Injury
Samarasinghe, Amali
Wong, Daniel
Cull, Gavin
Chakera, Aron
Marginal zone lymphoma causing accelerated progression of chronic kidney disease
title Marginal zone lymphoma causing accelerated progression of chronic kidney disease
title_full Marginal zone lymphoma causing accelerated progression of chronic kidney disease
title_fullStr Marginal zone lymphoma causing accelerated progression of chronic kidney disease
title_full_unstemmed Marginal zone lymphoma causing accelerated progression of chronic kidney disease
title_short Marginal zone lymphoma causing accelerated progression of chronic kidney disease
title_sort marginal zone lymphoma causing accelerated progression of chronic kidney disease
topic Unusual Presentation of More Common Disease/Injury
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855851/
https://www.ncbi.nlm.nih.gov/pubmed/31712228
http://dx.doi.org/10.1136/bcr-2019-230270
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