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Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication

A 40-year-old man developed aseptic meningitis after ibuprofen consumption for tension-type headaches. After a thorough diagnostic workup and lack of improvement on empirical therapy for common aetiologies of meningitis (bacterial and viral infections), we suspected non-steroidal anti-inflammatory d...

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Autores principales: Desgranges, Florian, Tebib, Nathalie, Lamy, Olivier, Kritikos, Antonios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855853/
https://www.ncbi.nlm.nih.gov/pubmed/31704799
http://dx.doi.org/10.1136/bcr-2019-231619
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author Desgranges, Florian
Tebib, Nathalie
Lamy, Olivier
Kritikos, Antonios
author_facet Desgranges, Florian
Tebib, Nathalie
Lamy, Olivier
Kritikos, Antonios
author_sort Desgranges, Florian
collection PubMed
description A 40-year-old man developed aseptic meningitis after ibuprofen consumption for tension-type headaches. After a thorough diagnostic workup and lack of improvement on empirical therapy for common aetiologies of meningitis (bacterial and viral infections), we suspected non-steroidal anti-inflammatory drug (NSAID) induced meningitis due to the temporal relationship between drug administration and symptom onset. Two days after NSAID suppression, the evolution was progressively favourable with complete resolution of fever and symptoms. On follow-up, symptoms did not recur and there was no neurological sequela. This article summarises the clinical picture and the complementary exams that led to the difficult-to-make diagnosis of NSAID-induced acute meningitis, in parallel with a brief review of the literature.
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spelling pubmed-68558532019-12-03 Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication Desgranges, Florian Tebib, Nathalie Lamy, Olivier Kritikos, Antonios BMJ Case Rep Rare Disease A 40-year-old man developed aseptic meningitis after ibuprofen consumption for tension-type headaches. After a thorough diagnostic workup and lack of improvement on empirical therapy for common aetiologies of meningitis (bacterial and viral infections), we suspected non-steroidal anti-inflammatory drug (NSAID) induced meningitis due to the temporal relationship between drug administration and symptom onset. Two days after NSAID suppression, the evolution was progressively favourable with complete resolution of fever and symptoms. On follow-up, symptoms did not recur and there was no neurological sequela. This article summarises the clinical picture and the complementary exams that led to the difficult-to-make diagnosis of NSAID-induced acute meningitis, in parallel with a brief review of the literature. BMJ Publishing Group 2019-11-07 /pmc/articles/PMC6855853/ /pubmed/31704799 http://dx.doi.org/10.1136/bcr-2019-231619 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Rare Disease
Desgranges, Florian
Tebib, Nathalie
Lamy, Olivier
Kritikos, Antonios
Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
title Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
title_full Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
title_fullStr Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
title_full_unstemmed Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
title_short Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
title_sort meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication
topic Rare Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855853/
https://www.ncbi.nlm.nih.gov/pubmed/31704799
http://dx.doi.org/10.1136/bcr-2019-231619
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