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Requirements to Establishing Confidence in Physiologically Based Pharmacokinetic (PBPK) Models and Overcoming Some of the Challenges to Meeting Them

When scientifically well-founded, the mechanistic basis of physiologically based pharmacokinetic (PBPK) models can help reduce the uncertainty and increase confidence in extrapolations outside the studied scenarios or studied populations. However, it is not always possible to establish mechanistical...

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Detalles Bibliográficos
Autores principales: Peters, Sheila Annie, Dolgos, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856026/
https://www.ncbi.nlm.nih.gov/pubmed/31236775
http://dx.doi.org/10.1007/s40262-019-00790-0

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