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Phase I study of TAS-121, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in patients with non-small-cell lung cancer harboring EGFR mutations

Purpose We investigated the safety, tolerability, pharmacokinetics, and efficacy of TAS-121, a novel, potent, and highly selective third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in Japanese patients with advanced EGFR mutation-positive non-small-cell lung canc...

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Detalles Bibliográficos
Autores principales:	Nishio, Makoto, Murakami, Haruyasu, Ohe, Yuichiro, Hida, Toyoaki, Sakai, Hiroshi, Kasahara, Kazuo, Imamura, Fumio, Baba, Tomohisa, Kubota, Kaoru, Hosomi, Yukio, Shimokawa, Tsuneo, Hayashi, Hidetoshi, Miyadera, Kazutaka, Tamura, Tomohide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2019
Materias:	Phase I Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856039/ https://www.ncbi.nlm.nih.gov/pubmed/30790152 http://dx.doi.org/10.1007/s10637-019-00732-4

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