Cargando…

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

The dynamic interaction of the N- and C-terminal domains of mycobacterial F-ATP synthase subunit ε is proposed to contribute to efficient coupling of H(+)-translocation and ATP synthesis. Here, we investigate crosstalk between both subunit ε domains by introducing chromosomal atpC missense mutations...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saw, Wuan-Geok, Wu, Mu-Lu, Ragunathan, Priya, Biuković, Goran, Lau, Aik-Meng, Shin, Joon, Harikishore, Amaravadhi, Cheung, Chen-Yi, Hards, Kiel, Sarathy, Jickky Palmae, Bates, Roderick W., Cook, Gregory M., Dick, Thomas, Grüber, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856130/ https://www.ncbi.nlm.nih.gov/pubmed/31727946 http://dx.doi.org/10.1038/s41598-019-53107-3

Ejemplares similares

TBAJ-876 Retains Bedaquiline’s Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase
por: Sarathy, Jickky Palmae, et al.
Publicado: (2019)

Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline
por: Sarathy, Jickky Palmae, et al.
Publicado: (2019)

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase
por: Kundu, Subhashri, et al.
Publicado: (2016)

Targeting Mycobacterial F-ATP Synthase C-Terminal α Subunit Interaction Motif on Rotary Subunit γ
por: Harikishore, Amaravadhi, et al.
Publicado: (2021)

TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug’s Uncoupler Activity
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria
por: Fridianto, Kevin Timothy, et al.
Publicado: (2022)

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C
por: Wong, Chui Fann, et al.
Publicado: (2017)

Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
por: Sarathy, Jickky Palmae, et al.
Publicado: (2022)

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Pyrazinamide triggers degradation of its target aspartate decarboxylase
por: Gopal, Pooja, et al.
Publicado: (2020)

Low-resolution structure of the soluble domain GPAA1 (yGPAA1(70–247)) of the glycosylphosphatidylinositol transamidase subunit GPAA1 from Saccharomyces cerevisiae
por: Saw, Wuan Geok, et al.
Publicado: (2013)

Targeting C-terminal Helical bundle of NCOVID19 Envelope (E) protein
por: Mukherjee, Shruti, et al.
Publicado: (2021)

Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst
por: Shetty, Annanya, et al.
Publicado: (2018)

Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent
por: Harikishore, Amaravadhi, et al.
Publicado: (2013)

Deciphering the Role of Ion Channels in Early Defense Signaling against Herbivorous Insects
por: Gandhi, Akanksha, et al.
Publicado: (2021)

Structures of mycobacterial ATP synthase bound to inhibitors
por: Courbon, Gautier M., et al.
Publicado: (2022)

Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase
por: Krah, Alexander, et al.
Publicado: (2022)

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
por: O'Malley, Theresa, et al.
Publicado: (2018)

Regulation of ATP hydrolysis by the ε subunit, ζ subunit and Mg-ADP in the ATP synthase of Paracoccus denitrificans
por: Jarman, Owen D., et al.
Publicado: (2021)

ATP binding by an F(1)F(o) ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria
por: Krah, Alexander, et al.
Publicado: (2023)

The structural basis of a high affinity ATP binding ε subunit from a bacterial ATP synthase
por: Krah, Alexander, et al.
Publicado: (2017)

Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase
por: Haagsma, Anna C., et al.
Publicado: (2011)

Antiviral activity against Middle East Respiratory Syndrome coronavirus by Montelukast, an anti-asthma drug
por: Gan, Hanjie Jonathan, et al.
Publicado: (2021)

Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing
por: Liang, Lujie, et al.
Publicado: (2022)

Current Progress In Orthopaedics
por: Aik, Saw
Publicado: (2015)

Structure of the mycobacterial ATP synthase F(o) rotor ring in complex with the anti-TB drug bedaquiline
por: Preiss, Laura, et al.
Publicado: (2015)

ATP-binding affinity of the ε subunit of thermophilic F(1)-ATPase under label-free conditions
por: Fujiwara, Miria, et al.
Publicado: (2020)

Boromycin Kills Mycobacterial Persisters without Detectable Resistance
por: Moreira, Wilfried, et al.
Publicado: (2016)

Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
por: Dounavi, Maria-Eleni, et al.
Publicado: (2021)

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
por: Knudsen, Jakob G., et al.
Publicado: (2019)

Luteolin Suppresses Cancer Cell Proliferation by Targeting Vaccinia-Related Kinase 1
por: Kim, Ye Seul, et al.
Publicado: (2014)

Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue
por: Dartois, Véronique, et al.
Publicado: (2022)

ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis
por: Shi, Jikang, et al.
Publicado: (2020)

Evaluation of the mycobacteriophage amplification assay for detection of physically and physiologically stressed mycobacterial cells in vitro
por: Cheah, Eddy SG, et al.
Publicado: (2014)

The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes
por: Mohamed, Jamaludin, et al.
Publicado: (2013)

Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization
por: Choi, Bo-Hwa, et al.
Publicado: (2014)

Correction: Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization
por: Choi, Bo-Hwa, et al.
Publicado: (2018)

Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins
por: Ganapathy, Uday S., et al.
Publicado: (2023)

Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase
por: Chao, Wen-Cheng, et al.
Publicado: (2017)

Profiling mycobacterial communities in pulmonary nontuberculous mycobacterial disease
por: Cowman, Steven A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3a4erfl3kpq9efcvlpeqc96d47