Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma

The loss of p16 is a signature event in Human Papilloma Virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) that leads to increased Cyclin Dependent Kinase 4/6 (CDK) signaling. Palbociclib, a CDK4/6 inhibitor, is active for the treatment of a subset of HNSCC. In this study, we analyze...

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Detalles Bibliográficos
Autores principales: Robinson, Anthony M., Rathore, Richa, Redlich, Nathan J., Adkins, Douglas R., VanArsdale, Todd, Van Tine, Brian A., Michel, Loren S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856201/
https://www.ncbi.nlm.nih.gov/pubmed/31727874
http://dx.doi.org/10.1038/s41419-019-2098-8

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