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Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, for the Treatment of Thrombocytopenia in Patients with Chronic Liver Disease Undergoing Invasive Procedures

BACKGROUND: Patients with thrombocytopenia associated with chronic liver disease (CLD) are at greater risk of bleeding during invasive procedures. This study characterized the pharmacokinetic/pharmacodynamic (PK/PD) profile of lusutrombopag, a novel thrombopoietin-receptor agonist, using modelling a...

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Detalles Bibliográficos
Autores principales:	Katsube, Takayuki, Shimizu, Ryosuke, Fukuhara, Takahiro, Kano, Takeshi, Wajima, Toshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856258/ https://www.ncbi.nlm.nih.gov/pubmed/31055790 http://dx.doi.org/10.1007/s40262-019-00770-4

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