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Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effect...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856359/ https://www.ncbi.nlm.nih.gov/pubmed/31727971 http://dx.doi.org/10.1038/s41598-019-53424-7 |
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author | Zainal, Zaida Rahim, Afiqah Abdul Radhakrishnan, Ammu Kutty Chang, Sui Kiat Khaza’ai, Huzwah |
author_facet | Zainal, Zaida Rahim, Afiqah Abdul Radhakrishnan, Ammu Kutty Chang, Sui Kiat Khaza’ai, Huzwah |
author_sort | Zainal, Zaida |
collection | PubMed |
description | The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA. |
format | Online Article Text |
id | pubmed-6856359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68563592019-12-17 Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo Zainal, Zaida Rahim, Afiqah Abdul Radhakrishnan, Ammu Kutty Chang, Sui Kiat Khaza’ai, Huzwah Sci Rep Article The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA. Nature Publishing Group UK 2019-11-14 /pmc/articles/PMC6856359/ /pubmed/31727971 http://dx.doi.org/10.1038/s41598-019-53424-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zainal, Zaida Rahim, Afiqah Abdul Radhakrishnan, Ammu Kutty Chang, Sui Kiat Khaza’ai, Huzwah Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo |
title | Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo |
title_full | Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo |
title_fullStr | Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo |
title_full_unstemmed | Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo |
title_short | Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo |
title_sort | investigation of the curative effects of palm vitamin e tocotrienols on autoimmune arthritis disease in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856359/ https://www.ncbi.nlm.nih.gov/pubmed/31727971 http://dx.doi.org/10.1038/s41598-019-53424-7 |
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