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Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo

The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effect...

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Autores principales: Zainal, Zaida, Rahim, Afiqah Abdul, Radhakrishnan, Ammu Kutty, Chang, Sui Kiat, Khaza’ai, Huzwah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856359/
https://www.ncbi.nlm.nih.gov/pubmed/31727971
http://dx.doi.org/10.1038/s41598-019-53424-7
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author Zainal, Zaida
Rahim, Afiqah Abdul
Radhakrishnan, Ammu Kutty
Chang, Sui Kiat
Khaza’ai, Huzwah
author_facet Zainal, Zaida
Rahim, Afiqah Abdul
Radhakrishnan, Ammu Kutty
Chang, Sui Kiat
Khaza’ai, Huzwah
author_sort Zainal, Zaida
collection PubMed
description The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA.
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spelling pubmed-68563592019-12-17 Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo Zainal, Zaida Rahim, Afiqah Abdul Radhakrishnan, Ammu Kutty Chang, Sui Kiat Khaza’ai, Huzwah Sci Rep Article The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA. Nature Publishing Group UK 2019-11-14 /pmc/articles/PMC6856359/ /pubmed/31727971 http://dx.doi.org/10.1038/s41598-019-53424-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zainal, Zaida
Rahim, Afiqah Abdul
Radhakrishnan, Ammu Kutty
Chang, Sui Kiat
Khaza’ai, Huzwah
Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_full Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_fullStr Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_full_unstemmed Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_short Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo
title_sort investigation of the curative effects of palm vitamin e tocotrienols on autoimmune arthritis disease in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856359/
https://www.ncbi.nlm.nih.gov/pubmed/31727971
http://dx.doi.org/10.1038/s41598-019-53424-7
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