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Release from Unc93b1 reinforces the compartmentalized activation of select TLRs
Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate recognition of microbial DNA and RNA while limiting recognition of self-nucleic acids(1). Failure to properly regulate these TLRs can lead to autoimmune and autoinflammatory disease(2–6). Intracellular lo...
Autores principales: | Majer, Olivia, Liu, Bo, Woo, Brian J, Kreuk, Lieselotte SM, Van Dis, Erik, Barton, Gregory M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856438/ https://www.ncbi.nlm.nih.gov/pubmed/31546247 http://dx.doi.org/10.1038/s41586-019-1611-7 |
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