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Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts

This study aimed to report three new cases of an association between two rare conditions, congenital portosystemic shunts (CPSS) and trimethylaminuria (TMAU), and the efficacy of endovascular closure of the CPSS for resolving TMAU. Between November 2014 and April 2017, 15 patients with CPSS were enr...

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Autores principales: Ponce-Dorrego, María Dolores, Garzón-Moll, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856509/
https://www.ncbi.nlm.nih.gov/pubmed/31777726
http://dx.doi.org/10.5223/pghn.2019.22.6.588
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author Ponce-Dorrego, María Dolores
Garzón-Moll, Gonzalo
author_facet Ponce-Dorrego, María Dolores
Garzón-Moll, Gonzalo
author_sort Ponce-Dorrego, María Dolores
collection PubMed
description This study aimed to report three new cases of an association between two rare conditions, congenital portosystemic shunts (CPSS) and trimethylaminuria (TMAU), and the efficacy of endovascular closure of the CPSS for resolving TMAU. Between November 2014 and April 2017, 15 patients with CPSS were enrolled in this prospective study to assess the efficacy of percutaneous endovascular shunt closure. Three patients presented with clinical symptoms of TMAU that were confirmed by urine analysis of trimethylamine (TMA) and TMA n-oxide. One year after endovascular closure of the congenital portosystemic shunt, the same parameters were evaluated were obtained and the values were compared to the pretreatment values. The results indicated the disappearance of clinical symptoms of TMAU and normalization of the urine test parameters in two patients and no changes in one patient, who developed new portosystemic communications.
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spelling pubmed-68565092019-11-27 Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts Ponce-Dorrego, María Dolores Garzón-Moll, Gonzalo Pediatr Gastroenterol Hepatol Nutr Case Report This study aimed to report three new cases of an association between two rare conditions, congenital portosystemic shunts (CPSS) and trimethylaminuria (TMAU), and the efficacy of endovascular closure of the CPSS for resolving TMAU. Between November 2014 and April 2017, 15 patients with CPSS were enrolled in this prospective study to assess the efficacy of percutaneous endovascular shunt closure. Three patients presented with clinical symptoms of TMAU that were confirmed by urine analysis of trimethylamine (TMA) and TMA n-oxide. One year after endovascular closure of the congenital portosystemic shunt, the same parameters were evaluated were obtained and the values were compared to the pretreatment values. The results indicated the disappearance of clinical symptoms of TMAU and normalization of the urine test parameters in two patients and no changes in one patient, who developed new portosystemic communications. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2019-11 2019-11-07 /pmc/articles/PMC6856509/ /pubmed/31777726 http://dx.doi.org/10.5223/pghn.2019.22.6.588 Text en Copyright © 2019 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition https://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ponce-Dorrego, María Dolores
Garzón-Moll, Gonzalo
Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts
title Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts
title_full Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts
title_fullStr Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts
title_full_unstemmed Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts
title_short Endovascular Closure Resolves Trimethylaminuria Caused by Congenital Portosystemic Shunts
title_sort endovascular closure resolves trimethylaminuria caused by congenital portosystemic shunts
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856509/
https://www.ncbi.nlm.nih.gov/pubmed/31777726
http://dx.doi.org/10.5223/pghn.2019.22.6.588
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