Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis

Microbial production of butyrate is impaired in patients with ulcerative colitis (UC); however, this inhibition is not well understood in Japanese UC patients. Therefore, we quantitatively analyzed genes encoding butyryl-CoA:acetate CoA-transferase (but) and butyrate kinase (buk) in the gut microbio...

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Autores principales: SHINOHARA, Ryohei, SASAKI, Kengo, INOUE, Jun, HOSHI, Namiko, FUKUDA, Itsuko, SASAKI, Daisuke, KONDO, Akihiko, OSAWA, Ro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMFH Press 2019
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856515/
https://www.ncbi.nlm.nih.gov/pubmed/31763119
http://dx.doi.org/10.12938/bmfh.18-029
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author SHINOHARA, Ryohei
SASAKI, Kengo
INOUE, Jun
HOSHI, Namiko
FUKUDA, Itsuko
SASAKI, Daisuke
KONDO, Akihiko
OSAWA, Ro
author_facet SHINOHARA, Ryohei
SASAKI, Kengo
INOUE, Jun
HOSHI, Namiko
FUKUDA, Itsuko
SASAKI, Daisuke
KONDO, Akihiko
OSAWA, Ro
author_sort SHINOHARA, Ryohei
collection PubMed
description Microbial production of butyrate is impaired in patients with ulcerative colitis (UC); however, this inhibition is not well understood in Japanese UC patients. Therefore, we quantitatively analyzed genes encoding butyryl-CoA:acetate CoA-transferase (but) and butyrate kinase (buk) in the gut microbiota of Japanese patients with UC and healthy volunteers (HVs). But showed higher levels than buk. Moreover, patients with UC showed significantly decreased levels of but associated with Roseburia sp./Eubacterium rectale compared with HVs. But, which is associated with Faecalibacterium sp., was maintained in patients with UC, with an unchanged relative abundance of Faecalibacterium sp. microorganisms in patients with UC compared with HVs.
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spelling pubmed-68565152019-11-22 Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis SHINOHARA, Ryohei SASAKI, Kengo INOUE, Jun HOSHI, Namiko FUKUDA, Itsuko SASAKI, Daisuke KONDO, Akihiko OSAWA, Ro Biosci Microbiota Food Health Note Microbial production of butyrate is impaired in patients with ulcerative colitis (UC); however, this inhibition is not well understood in Japanese UC patients. Therefore, we quantitatively analyzed genes encoding butyryl-CoA:acetate CoA-transferase (but) and butyrate kinase (buk) in the gut microbiota of Japanese patients with UC and healthy volunteers (HVs). But showed higher levels than buk. Moreover, patients with UC showed significantly decreased levels of but associated with Roseburia sp./Eubacterium rectale compared with HVs. But, which is associated with Faecalibacterium sp., was maintained in patients with UC, with an unchanged relative abundance of Faecalibacterium sp. microorganisms in patients with UC compared with HVs. BMFH Press 2019-06-26 2019 /pmc/articles/PMC6856515/ /pubmed/31763119 http://dx.doi.org/10.12938/bmfh.18-029 Text en ©2019 BMFH Press This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Note
SHINOHARA, Ryohei
SASAKI, Kengo
INOUE, Jun
HOSHI, Namiko
FUKUDA, Itsuko
SASAKI, Daisuke
KONDO, Akihiko
OSAWA, Ro
Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis
title Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis
title_full Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis
title_fullStr Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis
title_full_unstemmed Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis
title_short Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis
title_sort butyryl-coa:acetate coa-transferase gene associated with the genus roseburia is decreased in the gut microbiota of japanese patients with ulcerative colitis
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856515/
https://www.ncbi.nlm.nih.gov/pubmed/31763119
http://dx.doi.org/10.12938/bmfh.18-029
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