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The analgesic effect of refeeding on acute and chronic inflammatory pain

Pain is susceptible to various cognitive factors. Suppression of pain by hunger is well known, but the effect of food intake after fasting (i.e. refeeding) on pain remains unknown. In the present study, we examined whether inflammatory pain behavior is affected by 24 h fasting and 2 h refeeding. In...

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Autores principales: Lee, Jeong-Yun, Lee, Grace J., Lee, Pa Reum, Won, Chan Hee, Kim, Doyun, Kang, Youngnam, Oh, Seog Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856519/
https://www.ncbi.nlm.nih.gov/pubmed/31727949
http://dx.doi.org/10.1038/s41598-019-53149-7
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author Lee, Jeong-Yun
Lee, Grace J.
Lee, Pa Reum
Won, Chan Hee
Kim, Doyun
Kang, Youngnam
Oh, Seog Bae
author_facet Lee, Jeong-Yun
Lee, Grace J.
Lee, Pa Reum
Won, Chan Hee
Kim, Doyun
Kang, Youngnam
Oh, Seog Bae
author_sort Lee, Jeong-Yun
collection PubMed
description Pain is susceptible to various cognitive factors. Suppression of pain by hunger is well known, but the effect of food intake after fasting (i.e. refeeding) on pain remains unknown. In the present study, we examined whether inflammatory pain behavior is affected by 24 h fasting and 2 h refeeding. In formalin-induced acute inflammatory pain model, fasting suppressed pain behavior only in the second phase and the analgesic effect was also observed after refeeding. Furthermore, in Complete Freund’s adjuvant-induced chronic inflammatory pain model, both fasting and refeeding reduced spontaneous pain response. Refeeding with non-calorie agar produced an analgesic effect. Besides, intraperitoneal (i.p.) administration of glucose after fasting, which mimics calorie recovery following refeeding, induced analgesic effect. Administration of opioid receptor antagonist (naloxone, i.p.) and cannabinoid receptor antagonist (SR 141716, i.p.) reversed fasting-induced analgesia, but did not affect refeeding-induced analgesia in acute inflammatory pain model. Taken together, our results show that refeeding produce analgesia in inflammatory pain condition, which is associated with eating behavior and calorie recovery effect.
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spelling pubmed-68565192019-12-17 The analgesic effect of refeeding on acute and chronic inflammatory pain Lee, Jeong-Yun Lee, Grace J. Lee, Pa Reum Won, Chan Hee Kim, Doyun Kang, Youngnam Oh, Seog Bae Sci Rep Article Pain is susceptible to various cognitive factors. Suppression of pain by hunger is well known, but the effect of food intake after fasting (i.e. refeeding) on pain remains unknown. In the present study, we examined whether inflammatory pain behavior is affected by 24 h fasting and 2 h refeeding. In formalin-induced acute inflammatory pain model, fasting suppressed pain behavior only in the second phase and the analgesic effect was also observed after refeeding. Furthermore, in Complete Freund’s adjuvant-induced chronic inflammatory pain model, both fasting and refeeding reduced spontaneous pain response. Refeeding with non-calorie agar produced an analgesic effect. Besides, intraperitoneal (i.p.) administration of glucose after fasting, which mimics calorie recovery following refeeding, induced analgesic effect. Administration of opioid receptor antagonist (naloxone, i.p.) and cannabinoid receptor antagonist (SR 141716, i.p.) reversed fasting-induced analgesia, but did not affect refeeding-induced analgesia in acute inflammatory pain model. Taken together, our results show that refeeding produce analgesia in inflammatory pain condition, which is associated with eating behavior and calorie recovery effect. Nature Publishing Group UK 2019-11-14 /pmc/articles/PMC6856519/ /pubmed/31727949 http://dx.doi.org/10.1038/s41598-019-53149-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lee, Jeong-Yun
Lee, Grace J.
Lee, Pa Reum
Won, Chan Hee
Kim, Doyun
Kang, Youngnam
Oh, Seog Bae
The analgesic effect of refeeding on acute and chronic inflammatory pain
title The analgesic effect of refeeding on acute and chronic inflammatory pain
title_full The analgesic effect of refeeding on acute and chronic inflammatory pain
title_fullStr The analgesic effect of refeeding on acute and chronic inflammatory pain
title_full_unstemmed The analgesic effect of refeeding on acute and chronic inflammatory pain
title_short The analgesic effect of refeeding on acute and chronic inflammatory pain
title_sort analgesic effect of refeeding on acute and chronic inflammatory pain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856519/
https://www.ncbi.nlm.nih.gov/pubmed/31727949
http://dx.doi.org/10.1038/s41598-019-53149-7
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