Cargando…
Possible indication of endoscopic resection in undifferentiated early gastric cancer
Endoscopic resection for early gastric cancer (EGC) without lymph node metastasis may be a valuable treatment option. To date, endoscopic resection for undifferentiated EGC is being investigated. We evaluated the risk of lymph node metastasis in undifferentiated EGC by examining the preoperative end...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856523/ https://www.ncbi.nlm.nih.gov/pubmed/31728024 http://dx.doi.org/10.1038/s41598-019-53374-0 |
_version_ | 1783470584179458048 |
---|---|
author | Ryu, Dae Gon Choi, Cheol Woong Kim, Su Jin Kang, Dae Hwan Kim, Hyung Wook Park, Su Bum Nam, Hyeong Seok |
author_facet | Ryu, Dae Gon Choi, Cheol Woong Kim, Su Jin Kang, Dae Hwan Kim, Hyung Wook Park, Su Bum Nam, Hyeong Seok |
author_sort | Ryu, Dae Gon |
collection | PubMed |
description | Endoscopic resection for early gastric cancer (EGC) without lymph node metastasis may be a valuable treatment option. To date, endoscopic resection for undifferentiated EGC is being investigated. We evaluated the risk of lymph node metastasis in undifferentiated EGC by examining the preoperative endoscopic findings and operated pathologic specimen. The medical records of patients who underwent surgical resection because of undifferentiated EGC between November 2008 and December 2015 were reviewed retrospectively. The risk factors associated with lymph node metastasis and the lymph node metastasis rate in the expanded indication of undifferentiated EGC were evaluated. A total of 376 patients with undifferentiated EGC (233 signet ring cell type and 143 poorly differentiated type) were analyzed. Lymph node metastasis was found in 9.8% of the patients. Among the patients who met the expanded criteria (59 patients), only one patient had lymph node metastasis (signet ring cell type without ulceration and 15 mm in size). The risk factors associated with lymph node metastasis were lesion size >20 mm (OR 3.013), scar deformity (OR 2.248), surface depression (OR 2.360), submucosal invasion (OR 3.427), and lymphovascular invasion (OR 6.296). Before endoscopic resection of undifferentiated EGC, careful selection of patients should be considered. The undifferentiated EGC with size ≥15 mm, scar deformity, surface depression, submucosal invasion, and lymphovascular invasion should be considered surgical resection instead of endoscopic resection. |
format | Online Article Text |
id | pubmed-6856523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68565232019-12-17 Possible indication of endoscopic resection in undifferentiated early gastric cancer Ryu, Dae Gon Choi, Cheol Woong Kim, Su Jin Kang, Dae Hwan Kim, Hyung Wook Park, Su Bum Nam, Hyeong Seok Sci Rep Article Endoscopic resection for early gastric cancer (EGC) without lymph node metastasis may be a valuable treatment option. To date, endoscopic resection for undifferentiated EGC is being investigated. We evaluated the risk of lymph node metastasis in undifferentiated EGC by examining the preoperative endoscopic findings and operated pathologic specimen. The medical records of patients who underwent surgical resection because of undifferentiated EGC between November 2008 and December 2015 were reviewed retrospectively. The risk factors associated with lymph node metastasis and the lymph node metastasis rate in the expanded indication of undifferentiated EGC were evaluated. A total of 376 patients with undifferentiated EGC (233 signet ring cell type and 143 poorly differentiated type) were analyzed. Lymph node metastasis was found in 9.8% of the patients. Among the patients who met the expanded criteria (59 patients), only one patient had lymph node metastasis (signet ring cell type without ulceration and 15 mm in size). The risk factors associated with lymph node metastasis were lesion size >20 mm (OR 3.013), scar deformity (OR 2.248), surface depression (OR 2.360), submucosal invasion (OR 3.427), and lymphovascular invasion (OR 6.296). Before endoscopic resection of undifferentiated EGC, careful selection of patients should be considered. The undifferentiated EGC with size ≥15 mm, scar deformity, surface depression, submucosal invasion, and lymphovascular invasion should be considered surgical resection instead of endoscopic resection. Nature Publishing Group UK 2019-11-14 /pmc/articles/PMC6856523/ /pubmed/31728024 http://dx.doi.org/10.1038/s41598-019-53374-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ryu, Dae Gon Choi, Cheol Woong Kim, Su Jin Kang, Dae Hwan Kim, Hyung Wook Park, Su Bum Nam, Hyeong Seok Possible indication of endoscopic resection in undifferentiated early gastric cancer |
title | Possible indication of endoscopic resection in undifferentiated early gastric cancer |
title_full | Possible indication of endoscopic resection in undifferentiated early gastric cancer |
title_fullStr | Possible indication of endoscopic resection in undifferentiated early gastric cancer |
title_full_unstemmed | Possible indication of endoscopic resection in undifferentiated early gastric cancer |
title_short | Possible indication of endoscopic resection in undifferentiated early gastric cancer |
title_sort | possible indication of endoscopic resection in undifferentiated early gastric cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856523/ https://www.ncbi.nlm.nih.gov/pubmed/31728024 http://dx.doi.org/10.1038/s41598-019-53374-0 |
work_keys_str_mv | AT ryudaegon possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer AT choicheolwoong possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer AT kimsujin possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer AT kangdaehwan possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer AT kimhyungwook possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer AT parksubum possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer AT namhyeongseok possibleindicationofendoscopicresectioninundifferentiatedearlygastriccancer |