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Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between geneti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856594/ https://www.ncbi.nlm.nih.gov/pubmed/31762827 http://dx.doi.org/10.7150/jca.35917 |
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author | Gu, Cheng-Yuan Jin, Sheng-Ming Qin, Xiao-Jian Zhu, Yao Bo, Dai Lin, Guo-Wen Shi, Guo-Hai Ye, Ding-Wei |
author_facet | Gu, Cheng-Yuan Jin, Sheng-Ming Qin, Xiao-Jian Zhu, Yao Bo, Dai Lin, Guo-Wen Shi, Guo-Hai Ye, Ding-Wei |
author_sort | Gu, Cheng-Yuan |
collection | PubMed |
description | Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. RTEL1 rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, P = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. These two risk single nucleotide polymorphisms (SNPs) (OR: 0.59; 95% CI: 0.39-0.89, P = 0.012 and OR: 0.58; 95% CI: 0.38-0.87, P = 0.009, respectively) and another SNP PARP1 rs1136410 (OR: 1.53; 95% CI: 1.01-2.31, P = 0.043) were also associated with leukocyte telomere length. These findings support that genetic determinants of telomere length may influence PCa risk. |
format | Online Article Text |
id | pubmed-6856594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-68565942019-11-24 Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk Gu, Cheng-Yuan Jin, Sheng-Ming Qin, Xiao-Jian Zhu, Yao Bo, Dai Lin, Guo-Wen Shi, Guo-Hai Ye, Ding-Wei J Cancer Research Paper Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. RTEL1 rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, P = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. These two risk single nucleotide polymorphisms (SNPs) (OR: 0.59; 95% CI: 0.39-0.89, P = 0.012 and OR: 0.58; 95% CI: 0.38-0.87, P = 0.009, respectively) and another SNP PARP1 rs1136410 (OR: 1.53; 95% CI: 1.01-2.31, P = 0.043) were also associated with leukocyte telomere length. These findings support that genetic determinants of telomere length may influence PCa risk. Ivyspring International Publisher 2019-10-15 /pmc/articles/PMC6856594/ /pubmed/31762827 http://dx.doi.org/10.7150/jca.35917 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Gu, Cheng-Yuan Jin, Sheng-Ming Qin, Xiao-Jian Zhu, Yao Bo, Dai Lin, Guo-Wen Shi, Guo-Hai Ye, Ding-Wei Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk |
title | Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk |
title_full | Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk |
title_fullStr | Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk |
title_full_unstemmed | Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk |
title_short | Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk |
title_sort | genetic variants in rtel1 influencing telomere length are associated with prostate cancer risk |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856594/ https://www.ncbi.nlm.nih.gov/pubmed/31762827 http://dx.doi.org/10.7150/jca.35917 |
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