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Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk

Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between geneti...

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Autores principales: Gu, Cheng-Yuan, Jin, Sheng-Ming, Qin, Xiao-Jian, Zhu, Yao, Bo, Dai, Lin, Guo-Wen, Shi, Guo-Hai, Ye, Ding-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856594/
https://www.ncbi.nlm.nih.gov/pubmed/31762827
http://dx.doi.org/10.7150/jca.35917
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author Gu, Cheng-Yuan
Jin, Sheng-Ming
Qin, Xiao-Jian
Zhu, Yao
Bo, Dai
Lin, Guo-Wen
Shi, Guo-Hai
Ye, Ding-Wei
author_facet Gu, Cheng-Yuan
Jin, Sheng-Ming
Qin, Xiao-Jian
Zhu, Yao
Bo, Dai
Lin, Guo-Wen
Shi, Guo-Hai
Ye, Ding-Wei
author_sort Gu, Cheng-Yuan
collection PubMed
description Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. RTEL1 rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, P = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. These two risk single nucleotide polymorphisms (SNPs) (OR: 0.59; 95% CI: 0.39-0.89, P = 0.012 and OR: 0.58; 95% CI: 0.38-0.87, P = 0.009, respectively) and another SNP PARP1 rs1136410 (OR: 1.53; 95% CI: 1.01-2.31, P = 0.043) were also associated with leukocyte telomere length. These findings support that genetic determinants of telomere length may influence PCa risk.
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spelling pubmed-68565942019-11-24 Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk Gu, Cheng-Yuan Jin, Sheng-Ming Qin, Xiao-Jian Zhu, Yao Bo, Dai Lin, Guo-Wen Shi, Guo-Hai Ye, Ding-Wei J Cancer Research Paper Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. RTEL1 rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, P = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. These two risk single nucleotide polymorphisms (SNPs) (OR: 0.59; 95% CI: 0.39-0.89, P = 0.012 and OR: 0.58; 95% CI: 0.38-0.87, P = 0.009, respectively) and another SNP PARP1 rs1136410 (OR: 1.53; 95% CI: 1.01-2.31, P = 0.043) were also associated with leukocyte telomere length. These findings support that genetic determinants of telomere length may influence PCa risk. Ivyspring International Publisher 2019-10-15 /pmc/articles/PMC6856594/ /pubmed/31762827 http://dx.doi.org/10.7150/jca.35917 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Gu, Cheng-Yuan
Jin, Sheng-Ming
Qin, Xiao-Jian
Zhu, Yao
Bo, Dai
Lin, Guo-Wen
Shi, Guo-Hai
Ye, Ding-Wei
Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
title Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
title_full Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
title_fullStr Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
title_full_unstemmed Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
title_short Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
title_sort genetic variants in rtel1 influencing telomere length are associated with prostate cancer risk
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856594/
https://www.ncbi.nlm.nih.gov/pubmed/31762827
http://dx.doi.org/10.7150/jca.35917
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