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ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in individuals on combined antiretroviral therapy (cART) with undetectable viremia. In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machiner...

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Detalles Bibliográficos
Autores principales:	Zhao, Juan, Nguyen, Lam Ngoc Thao, Nguyen, Lam Nhat, Dang, Xindi, Cao, Dechao, Khanal, Sushant, Schank, Madison, Thakuri, Bal Krishna Chand, Ogbu, Stella C., Morrison, Zheng D., Wu, Xiao Y., Li, Zhengke, Zou, Yue, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P., Yao, Zhi Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856652/ https://www.ncbi.nlm.nih.gov/pubmed/31781094 http://dx.doi.org/10.3389/fimmu.2019.02531

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