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Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation

Common approaches to antibiotic discovery include small-molecule screens for growth inhibition in target pathogens and screens for inhibitors of purified enzymes. These approaches have a shared intent of seeking to directly target a vital Achilles heel in a pathogen of interest. Here, we report the...

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Detalles Bibliográficos
Autores principales:	McAuley, Scott, Huynh, Alan, Howells, Alison, Walpole, Chris, Maxwell, Anthony, Nodwell, Justin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856721/ https://www.ncbi.nlm.nih.gov/pubmed/31279606 http://dx.doi.org/10.1016/j.chembiol.2019.06.002

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