The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P(3), but how neurons are able to generate sufficient PI(3,4,5)P(3) in the presence of high levels of the antagonizing phosphatase PTEN is difficult to reconcile. We fin...

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Detalles Bibliográficos
Autores principales: Brosig, Annika, Fuchs, Joachim, Ipek, Fatih, Kroon, Cristina, Schrötter, Sandra, Vadhvani, Mayur, Polyzou, Alexandra, Ledderose, Julia, van Diepen, Michiel, Holzhütter, Hermann-Georg, Trimbuch, Thorsten, Gimber, Niclas, Schmoranzer, Jan, Lieberam, Ivo, Rosenmund, Christian, Spahn, Christian, Scheerer, Patrick, Szczepek, Michal, Leondaritis, George, Eickholt, Britta J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856728/
https://www.ncbi.nlm.nih.gov/pubmed/31722215
http://dx.doi.org/10.1016/j.celrep.2019.10.039

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